Therapeutic strategies in inflammasome mediated diseases of the liver

Summary Tissue stress and cell death result in inflammation even in the absence of pathogens. Such sterile inflammation is dependent on a cytosolic complex of proteins inside immune cells termed the inflammasome. This complex converts two groups of extracellular signals into an inflammatory response...

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Veröffentlicht in:	Journal of hepatology 2013-05, Vol.58 (5), p.1047-1052
Hauptverfasser:	Hoque, Rafaz, Vodovotz, Yoram, Mehal, Wajahat
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Caspase 1 - physiology Cytokines - physiology Disease Models, Animal Gastroenterology and Hepatology Humans Inflammasomes - physiology Inflammation - physiopathology Liver Diseases - physiopathology Liver Diseases - therapy Signal Transduction - physiology
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