p53 suppresses carcinoma progression by inhibiting mTOR pathway activation

Genetic alterations in human cancers and murine models indicate that retinoblastoma (Rb) and p53 have critical tumor suppressive functions in retinoblastoma, a tumor of neural origin, and neuroendocrine tumors including small cell lung cancer and medullary thyroid cancer (MTC). Rb inactivation is th...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Oncogene 2015-01, Vol.34 (5), p.589-599
Hauptverfasser:	Akeno, N, Miller, A L, Ma, X, Wikenheiser-Brokamp, K A
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/581 631/80/86 692/420/755 692/699/67/1459/1843 AKT protein Analysis Animal models Animals Apoptosis Apoptosis - drug effects Cancer Carcinogenesis Carcinoma, Neuroendocrine Cell Biology Cell cycle Cell Line, Tumor Cell Proliferation - drug effects Cell Transformation, Neoplastic - drug effects Cell Transformation, Neoplastic - genetics Development and progression Genetic aspects Genetic engineering Human Genetics Humans Internal Medicine Kinases MAP kinase Medicine Medicine & Public Health Mice Mimicry Mitogen-Activated Protein Kinases - metabolism Neuroendocrine tumors Oncology original-article p53 Protein Physiological aspects Protein kinase Proteins Rapamycin Retina Retinoblastoma Retinoblastoma Protein - genetics Retinoblastoma Protein - metabolism Risk factors Rodents Signal transduction Signal Transduction - drug effects Sirolimus - administration & dosage Small cell lung carcinoma Studies Thyroid cancer Thyroid gland Thyroid Neoplasms - genetics Thyroid Neoplasms - pathology TOR protein TOR Serine-Threonine Kinases - genetics TOR Serine-Threonine Kinases - metabolism Tumor proteins Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumorigenesis Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!