Combat-related blast exposure and traumatic brain injury influence brain glucose metabolism during REM sleep in military veterans
Traumatic brain injury (TBI), a signature wound of Operations Enduring and Iraqi Freedom, can result from blunt head trauma or exposure to a blast/explosion. While TBI affects sleep, the neurobiological underpinnings between TBI and sleep are largely unknown. To examine the neurobiological underpinn...
Gespeichert in:
| Veröffentlicht in: | NeuroImage (Orlando, Fla.) Fla.), 2014-10, Vol.99, p.207-214 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 214 |
|---|---|
| container_issue | |
| container_start_page | 207 |
| container_title | NeuroImage (Orlando, Fla.) |
| container_volume | 99 |
| creator | Stocker, Ryan P.J. Cieply, Marissa A. Paul, Benjamin Khan, Hassen Henry, Luke Kontos, Anthony P. Germain, Anne |
| description | Traumatic brain injury (TBI), a signature wound of Operations Enduring and Iraqi Freedom, can result from blunt head trauma or exposure to a blast/explosion. While TBI affects sleep, the neurobiological underpinnings between TBI and sleep are largely unknown. To examine the neurobiological underpinnings of this relationship in military veterans, [18F]-fluorodeoxyglucose positron emission tomography (FDG PET) was used to compare mTBI-related changes in relative cerebral metabolic rate of glucose (rCMRglc) during wakefulness, Rapid Eye Movement (REM) sleep, and non-REM (NREM) sleep, after adjusting for the effects of posttraumatic stress (PTS). Fourteen veterans with a history of blast exposure and/or mTBI (B/mTBI) (age 27.5±3.9) and eleven veterans with no history (No B/mTBI) (age 28.1±4.3) completed FDG PET studies during wakefulness, REM sleep, and NREM sleep. Whole-brain analyses were conducted using Statistical Parametric Mapping (SPM8). Between group comparisons revealed that B/mTBI was associated with significantly lower rCMRglc during wakefulness and REM sleep in the amygdala, hippocampus, parahippocampal gyrus, thalamus, insula, uncus, culmen, visual association cortices, and midline medial frontal cortices. These results suggest that alterations in neurobiological networks during wakefulness and REM sleep subsequent to B/mTBI exposure may contribute to chronic sleep disturbances and differ in individuals with acute symptoms.
•Results showed decreased rCMRglc during wakefulness and REM sleep in blast and/or mTBI exposure.•Hypometabolism in right basal ganglia and limbic system.•Hypometabolism in culmen, associative visual cortices, and frontal cortices.•These effects are beyond concurrent PTSD symptoms, combat, and sleep quality.•Hypometabolic profile may reflect long-term neural effects of blast/TBI exposure. |
| doi_str_mv | 10.1016/j.neuroimage.2014.05.067 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4112017</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1053811914004522</els_id><sourcerecordid>1549200802</sourcerecordid><originalsourceid>FETCH-LOGICAL-c570t-b5c6f3ed8edf39f785dbe50e18b36108949ae2ffe145d59fff1373b3b68399bf3</originalsourceid><addsrcrecordid>eNqNksuKFDEUhgtRnHH0FSQggptqk0qlKtkITjNeYEQQXYckddKmSSVtkmqcpW9umm5n1I1uckLy_Ydz-ZsGEbwimAwvt6sAS4puVhtYdZj0K8xWeBjvNecEC9YKNnb3D3dGW06IOGse5bzFGAvS84fNWddzQWnXnTc_1nHWqrQJvCowIe1VLgi-72JeEiAVJlSSWmZVnEE6KReQC9sl3dRg_QLBwOl54xcTM6AZitLRuzyjaUkubNCnqw8oe4Bd1aDZeVdU1e-hQFIhP24eWOUzPDnFi-bLm6vP63ft9ce379evr1vDRlxazcxgKUwcJkuFHTmbNDAMhGs6EMxFLxR01gLp2cSEtZbQkWqqB06F0JZeNK-OeXeLnmEyEGpjXu5SnWK6kVE5-edPcF_lJu5lT0gd8VgTvDglSPHbArnI2WUD3qsAccmSMMZwPQb8H2gvOow57ir67C90G5cU6iQO1Ci6oaesUvxImRRzTmBv6yZYHiwht_LOEvJgCYmZrJao0qe_930r_OWBCjw_ASob5W1dinH5juMjJtVDlbs8clC3tHeQZDbuYIDJJTBFTtH9u5qfIC7dTg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1547926435</pqid></control><display><type>article</type><title>Combat-related blast exposure and traumatic brain injury influence brain glucose metabolism during REM sleep in military veterans</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><source>ProQuest Central UK/Ireland</source><creator>Stocker, Ryan P.J. ; Cieply, Marissa A. ; Paul, Benjamin ; Khan, Hassen ; Henry, Luke ; Kontos, Anthony P. ; Germain, Anne</creator><creatorcontrib>Stocker, Ryan P.J. ; Cieply, Marissa A. ; Paul, Benjamin ; Khan, Hassen ; Henry, Luke ; Kontos, Anthony P. ; Germain, Anne</creatorcontrib><description>Traumatic brain injury (TBI), a signature wound of Operations Enduring and Iraqi Freedom, can result from blunt head trauma or exposure to a blast/explosion. While TBI affects sleep, the neurobiological underpinnings between TBI and sleep are largely unknown. To examine the neurobiological underpinnings of this relationship in military veterans, [18F]-fluorodeoxyglucose positron emission tomography (FDG PET) was used to compare mTBI-related changes in relative cerebral metabolic rate of glucose (rCMRglc) during wakefulness, Rapid Eye Movement (REM) sleep, and non-REM (NREM) sleep, after adjusting for the effects of posttraumatic stress (PTS). Fourteen veterans with a history of blast exposure and/or mTBI (B/mTBI) (age 27.5±3.9) and eleven veterans with no history (No B/mTBI) (age 28.1±4.3) completed FDG PET studies during wakefulness, REM sleep, and NREM sleep. Whole-brain analyses were conducted using Statistical Parametric Mapping (SPM8). Between group comparisons revealed that B/mTBI was associated with significantly lower rCMRglc during wakefulness and REM sleep in the amygdala, hippocampus, parahippocampal gyrus, thalamus, insula, uncus, culmen, visual association cortices, and midline medial frontal cortices. These results suggest that alterations in neurobiological networks during wakefulness and REM sleep subsequent to B/mTBI exposure may contribute to chronic sleep disturbances and differ in individuals with acute symptoms.
•Results showed decreased rCMRglc during wakefulness and REM sleep in blast and/or mTBI exposure.•Hypometabolism in right basal ganglia and limbic system.•Hypometabolism in culmen, associative visual cortices, and frontal cortices.•These effects are beyond concurrent PTSD symptoms, combat, and sleep quality.•Hypometabolic profile may reflect long-term neural effects of blast/TBI exposure.</description><identifier>ISSN: 1053-8119</identifier><identifier>EISSN: 1095-9572</identifier><identifier>DOI: 10.1016/j.neuroimage.2014.05.067</identifier><identifier>PMID: 24893322</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Adult ; Biological and medical sciences ; Blast exposure ; Blast Injuries - diagnostic imaging ; Blast Injuries - metabolism ; Brain Chemistry ; Brain damage ; Brain Injuries - diagnostic imaging ; Brain Injuries - metabolism ; Brain research ; Cerebral glucose metabolism ; Combat Disorders - diagnostic imaging ; Combat Disorders - metabolism ; Consciousness ; Female ; Fluorodeoxyglucose F18 ; Fundamental and applied biological sciences. Psychology ; Glucose - metabolism ; Head injuries ; Humans ; Injuries of the nervous system and the skull. Diseases due to physical agents ; Insomnia ; Male ; Medical sciences ; Metabolism ; Military veterans ; mTBI ; Polysomnography ; Positron-Emission Tomography ; Rapid eye movement sleep ; Sleep, REM ; Sleep. Vigilance ; Stress Disorders, Post-Traumatic - diagnostic imaging ; Stress Disorders, Post-Traumatic - metabolism ; Studies ; Traumas. Diseases due to physical agents ; Vertebrates: nervous system and sense organs ; Veterans</subject><ispartof>NeuroImage (Orlando, Fla.), 2014-10, Vol.99, p.207-214</ispartof><rights>2014 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2014 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Oct 1, 2014</rights><rights>2014 Elsevier Inc. All rights reserved. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c570t-b5c6f3ed8edf39f785dbe50e18b36108949ae2ffe145d59fff1373b3b68399bf3</citedby><cites>FETCH-LOGICAL-c570t-b5c6f3ed8edf39f785dbe50e18b36108949ae2ffe145d59fff1373b3b68399bf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1547926435?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>230,314,777,781,882,3537,27905,27906,45976,64364,64366,64368,72218</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28701119$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24893322$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stocker, Ryan P.J.</creatorcontrib><creatorcontrib>Cieply, Marissa A.</creatorcontrib><creatorcontrib>Paul, Benjamin</creatorcontrib><creatorcontrib>Khan, Hassen</creatorcontrib><creatorcontrib>Henry, Luke</creatorcontrib><creatorcontrib>Kontos, Anthony P.</creatorcontrib><creatorcontrib>Germain, Anne</creatorcontrib><title>Combat-related blast exposure and traumatic brain injury influence brain glucose metabolism during REM sleep in military veterans</title><title>NeuroImage (Orlando, Fla.)</title><addtitle>Neuroimage</addtitle><description>Traumatic brain injury (TBI), a signature wound of Operations Enduring and Iraqi Freedom, can result from blunt head trauma or exposure to a blast/explosion. While TBI affects sleep, the neurobiological underpinnings between TBI and sleep are largely unknown. To examine the neurobiological underpinnings of this relationship in military veterans, [18F]-fluorodeoxyglucose positron emission tomography (FDG PET) was used to compare mTBI-related changes in relative cerebral metabolic rate of glucose (rCMRglc) during wakefulness, Rapid Eye Movement (REM) sleep, and non-REM (NREM) sleep, after adjusting for the effects of posttraumatic stress (PTS). Fourteen veterans with a history of blast exposure and/or mTBI (B/mTBI) (age 27.5±3.9) and eleven veterans with no history (No B/mTBI) (age 28.1±4.3) completed FDG PET studies during wakefulness, REM sleep, and NREM sleep. Whole-brain analyses were conducted using Statistical Parametric Mapping (SPM8). Between group comparisons revealed that B/mTBI was associated with significantly lower rCMRglc during wakefulness and REM sleep in the amygdala, hippocampus, parahippocampal gyrus, thalamus, insula, uncus, culmen, visual association cortices, and midline medial frontal cortices. These results suggest that alterations in neurobiological networks during wakefulness and REM sleep subsequent to B/mTBI exposure may contribute to chronic sleep disturbances and differ in individuals with acute symptoms.
•Results showed decreased rCMRglc during wakefulness and REM sleep in blast and/or mTBI exposure.•Hypometabolism in right basal ganglia and limbic system.•Hypometabolism in culmen, associative visual cortices, and frontal cortices.•These effects are beyond concurrent PTSD symptoms, combat, and sleep quality.•Hypometabolic profile may reflect long-term neural effects of blast/TBI exposure.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Blast exposure</subject><subject>Blast Injuries - diagnostic imaging</subject><subject>Blast Injuries - metabolism</subject><subject>Brain Chemistry</subject><subject>Brain damage</subject><subject>Brain Injuries - diagnostic imaging</subject><subject>Brain Injuries - metabolism</subject><subject>Brain research</subject><subject>Cerebral glucose metabolism</subject><subject>Combat Disorders - diagnostic imaging</subject><subject>Combat Disorders - metabolism</subject><subject>Consciousness</subject><subject>Female</subject><subject>Fluorodeoxyglucose F18</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glucose - metabolism</subject><subject>Head injuries</subject><subject>Humans</subject><subject>Injuries of the nervous system and the skull. Diseases due to physical agents</subject><subject>Insomnia</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolism</subject><subject>Military veterans</subject><subject>mTBI</subject><subject>Polysomnography</subject><subject>Positron-Emission Tomography</subject><subject>Rapid eye movement sleep</subject><subject>Sleep, REM</subject><subject>Sleep. Vigilance</subject><subject>Stress Disorders, Post-Traumatic - diagnostic imaging</subject><subject>Stress Disorders, Post-Traumatic - metabolism</subject><subject>Studies</subject><subject>Traumas. Diseases due to physical agents</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>Veterans</subject><issn>1053-8119</issn><issn>1095-9572</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNksuKFDEUhgtRnHH0FSQggptqk0qlKtkITjNeYEQQXYckddKmSSVtkmqcpW9umm5n1I1uckLy_Ydz-ZsGEbwimAwvt6sAS4puVhtYdZj0K8xWeBjvNecEC9YKNnb3D3dGW06IOGse5bzFGAvS84fNWddzQWnXnTc_1nHWqrQJvCowIe1VLgi-72JeEiAVJlSSWmZVnEE6KReQC9sl3dRg_QLBwOl54xcTM6AZitLRuzyjaUkubNCnqw8oe4Bd1aDZeVdU1e-hQFIhP24eWOUzPDnFi-bLm6vP63ft9ce379evr1vDRlxazcxgKUwcJkuFHTmbNDAMhGs6EMxFLxR01gLp2cSEtZbQkWqqB06F0JZeNK-OeXeLnmEyEGpjXu5SnWK6kVE5-edPcF_lJu5lT0gd8VgTvDglSPHbArnI2WUD3qsAccmSMMZwPQb8H2gvOow57ir67C90G5cU6iQO1Ci6oaesUvxImRRzTmBv6yZYHiwht_LOEvJgCYmZrJao0qe_930r_OWBCjw_ASob5W1dinH5juMjJtVDlbs8clC3tHeQZDbuYIDJJTBFTtH9u5qfIC7dTg</recordid><startdate>20141001</startdate><enddate>20141001</enddate><creator>Stocker, Ryan P.J.</creator><creator>Cieply, Marissa A.</creator><creator>Paul, Benjamin</creator><creator>Khan, Hassen</creator><creator>Henry, Luke</creator><creator>Kontos, Anthony P.</creator><creator>Germain, Anne</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><scope>7QO</scope><scope>5PM</scope></search><sort><creationdate>20141001</creationdate><title>Combat-related blast exposure and traumatic brain injury influence brain glucose metabolism during REM sleep in military veterans</title><author>Stocker, Ryan P.J. ; Cieply, Marissa A. ; Paul, Benjamin ; Khan, Hassen ; Henry, Luke ; Kontos, Anthony P. ; Germain, Anne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c570t-b5c6f3ed8edf39f785dbe50e18b36108949ae2ffe145d59fff1373b3b68399bf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Blast exposure</topic><topic>Blast Injuries - diagnostic imaging</topic><topic>Blast Injuries - metabolism</topic><topic>Brain Chemistry</topic><topic>Brain damage</topic><topic>Brain Injuries - diagnostic imaging</topic><topic>Brain Injuries - metabolism</topic><topic>Brain research</topic><topic>Cerebral glucose metabolism</topic><topic>Combat Disorders - diagnostic imaging</topic><topic>Combat Disorders - metabolism</topic><topic>Consciousness</topic><topic>Female</topic><topic>Fluorodeoxyglucose F18</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glucose - metabolism</topic><topic>Head injuries</topic><topic>Humans</topic><topic>Injuries of the nervous system and the skull. Diseases due to physical agents</topic><topic>Insomnia</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolism</topic><topic>Military veterans</topic><topic>mTBI</topic><topic>Polysomnography</topic><topic>Positron-Emission Tomography</topic><topic>Rapid eye movement sleep</topic><topic>Sleep, REM</topic><topic>Sleep. Vigilance</topic><topic>Stress Disorders, Post-Traumatic - diagnostic imaging</topic><topic>Stress Disorders, Post-Traumatic - metabolism</topic><topic>Studies</topic><topic>Traumas. Diseases due to physical agents</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>Veterans</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stocker, Ryan P.J.</creatorcontrib><creatorcontrib>Cieply, Marissa A.</creatorcontrib><creatorcontrib>Paul, Benjamin</creatorcontrib><creatorcontrib>Khan, Hassen</creatorcontrib><creatorcontrib>Henry, Luke</creatorcontrib><creatorcontrib>Kontos, Anthony P.</creatorcontrib><creatorcontrib>Germain, Anne</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>NeuroImage (Orlando, Fla.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stocker, Ryan P.J.</au><au>Cieply, Marissa A.</au><au>Paul, Benjamin</au><au>Khan, Hassen</au><au>Henry, Luke</au><au>Kontos, Anthony P.</au><au>Germain, Anne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Combat-related blast exposure and traumatic brain injury influence brain glucose metabolism during REM sleep in military veterans</atitle><jtitle>NeuroImage (Orlando, Fla.)</jtitle><addtitle>Neuroimage</addtitle><date>2014-10-01</date><risdate>2014</risdate><volume>99</volume><spage>207</spage><epage>214</epage><pages>207-214</pages><issn>1053-8119</issn><eissn>1095-9572</eissn><abstract>Traumatic brain injury (TBI), a signature wound of Operations Enduring and Iraqi Freedom, can result from blunt head trauma or exposure to a blast/explosion. While TBI affects sleep, the neurobiological underpinnings between TBI and sleep are largely unknown. To examine the neurobiological underpinnings of this relationship in military veterans, [18F]-fluorodeoxyglucose positron emission tomography (FDG PET) was used to compare mTBI-related changes in relative cerebral metabolic rate of glucose (rCMRglc) during wakefulness, Rapid Eye Movement (REM) sleep, and non-REM (NREM) sleep, after adjusting for the effects of posttraumatic stress (PTS). Fourteen veterans with a history of blast exposure and/or mTBI (B/mTBI) (age 27.5±3.9) and eleven veterans with no history (No B/mTBI) (age 28.1±4.3) completed FDG PET studies during wakefulness, REM sleep, and NREM sleep. Whole-brain analyses were conducted using Statistical Parametric Mapping (SPM8). Between group comparisons revealed that B/mTBI was associated with significantly lower rCMRglc during wakefulness and REM sleep in the amygdala, hippocampus, parahippocampal gyrus, thalamus, insula, uncus, culmen, visual association cortices, and midline medial frontal cortices. These results suggest that alterations in neurobiological networks during wakefulness and REM sleep subsequent to B/mTBI exposure may contribute to chronic sleep disturbances and differ in individuals with acute symptoms.
•Results showed decreased rCMRglc during wakefulness and REM sleep in blast and/or mTBI exposure.•Hypometabolism in right basal ganglia and limbic system.•Hypometabolism in culmen, associative visual cortices, and frontal cortices.•These effects are beyond concurrent PTSD symptoms, combat, and sleep quality.•Hypometabolic profile may reflect long-term neural effects of blast/TBI exposure.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>24893322</pmid><doi>10.1016/j.neuroimage.2014.05.067</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1053-8119 |
| ispartof | NeuroImage (Orlando, Fla.), 2014-10, Vol.99, p.207-214 |
| issn | 1053-8119 1095-9572 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4112017 |
| source | MEDLINE; Elsevier ScienceDirect Journals; ProQuest Central UK/Ireland |
| subjects | Adult Biological and medical sciences Blast exposure Blast Injuries - diagnostic imaging Blast Injuries - metabolism Brain Chemistry Brain damage Brain Injuries - diagnostic imaging Brain Injuries - metabolism Brain research Cerebral glucose metabolism Combat Disorders - diagnostic imaging Combat Disorders - metabolism Consciousness Female Fluorodeoxyglucose F18 Fundamental and applied biological sciences. Psychology Glucose - metabolism Head injuries Humans Injuries of the nervous system and the skull. Diseases due to physical agents Insomnia Male Medical sciences Metabolism Military veterans mTBI Polysomnography Positron-Emission Tomography Rapid eye movement sleep Sleep, REM Sleep. Vigilance Stress Disorders, Post-Traumatic - diagnostic imaging Stress Disorders, Post-Traumatic - metabolism Studies Traumas. Diseases due to physical agents Vertebrates: nervous system and sense organs Veterans |
| title | Combat-related blast exposure and traumatic brain injury influence brain glucose metabolism during REM sleep in military veterans |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T14%3A17%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Combat-related%20blast%20exposure%20and%20traumatic%20brain%20injury%20influence%20brain%20glucose%20metabolism%20during%20REM%20sleep%20in%20military%20veterans&rft.jtitle=NeuroImage%20(Orlando,%20Fla.)&rft.au=Stocker,%20Ryan%20P.J.&rft.date=2014-10-01&rft.volume=99&rft.spage=207&rft.epage=214&rft.pages=207-214&rft.issn=1053-8119&rft.eissn=1095-9572&rft_id=info:doi/10.1016/j.neuroimage.2014.05.067&rft_dat=%3Cproquest_pubme%3E1549200802%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1547926435&rft_id=info:pmid/24893322&rft_els_id=S1053811914004522&rfr_iscdi=true |