Stromal cell-derived factor-1 (SDF-1)/chemokine (C-X-C motif) receptor 4 (CXCR4) axis activation induces intra-islet glucagon-like peptide-1 (GLP-1) production and enhances beta cell survival

Aims/hypothesis The endogenous production of stromal cell-derived factor-1 (SDF-1) in beta cells in transgenic mice attenuates the development of diabetes in response to streptozotocin. Here we propose that beta cell injury induces SDF-1 production, and the SDF-1/chemokine (C-X-C motif) receptor 4 (...

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Veröffentlicht in:	Diabetologia 2011-08, Vol.54 (8), p.2067-2076
Hauptverfasser:	Liu, Z., Stanojevic, V., Avadhani, S., Yano, T., Habener, J. F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell growth Cell Line Cell Survival - drug effects Chemokine CXCL12 - genetics Chemokine CXCL12 - metabolism Chemokine CXCL12 - pharmacology Chemokines Diabetes Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Glucagon Glucagon-Like Peptide 1 - metabolism Human Physiology Humans Hypotheses In Vitro Techniques Insulin resistance Insulin-Secreting Cells - cytology Insulin-Secreting Cells - drug effects Insulin-Secreting Cells - metabolism Internal Medicine Islets of Langerhans - drug effects Islets of Langerhans - metabolism Kinases Male Medical sciences Medicine Medicine & Public Health Metabolic Diseases Mice Mice, Inbred C57BL Pancreas Pancreas - cytology Peptides Rats Receptors, CXCR4 - metabolism Reverse Transcriptase Polymerase Chain Reaction Transgenic animals
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