Modification of Rifamycin Polyketide Backbone Leads to Improved Drug Activity against Rifampicin-resistant Mycobacterium tuberculosis

Rifamycin B, a product of Amycolatopsis mediterranei S699, is the precursor of clinically used antibiotics that are effective against tuberculosis, leprosy, and AIDS-related mycobacterial infections. However, prolonged usage of these antibiotics has resulted in the emergence of rifamycin-resistant s...

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Veröffentlicht in:	The Journal of biological chemistry 2014-07, Vol.289 (30), p.21142-21152
Hauptverfasser:	Nigam, Aeshna, Almabruk, Khaled H., Saxena, Anjali, Yang, Jongtae, Mukherjee, Udita, Kaur, Hardeep, Kohli, Puneet, Kumari, Rashmi, Singh, Priya, Zakharov, Lev N., Singh, Yogendra, Mahmud, Taifo, Lal, Rup
Format:	Artikel
Sprache:	eng
Schlagworte:	24-Desmethylrifamycin Acyltransferases - genetics Acyltransferases - metabolism Antibiotics, Antitubercular - biosynthesis Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - metabolism Bioengineering Domain Swapping Drug Action Drug Design Drug Discovery Drug Resistance, Bacterial Microbiology Molecular Genetics Multiple Drug-resistant Mycobacterium tuberculosis Polyketide Synthase Polyketide Synthases - chemistry Polyketide Synthases - genetics Polyketide Synthases - metabolism Protein Engineering Rifampin - analogs & derivatives Rifampin - metabolism Rifamycin Analogs
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