Activated BRAF induces gliomas in mice when combined with Ink4a/Arf loss or Akt activation

Mutations in receptor tyrosine kinase (RTK) growth factor receptors ( epidermal growth factor receptor , platelet-derived growth factor receptor , MET and ERBB2) , which result in downstream activation of the RAS/RAF/MEK/ERK mitogen-activated protein kinase (MAPK) pathway and PI(3)K/Akt pathway, are...

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Veröffentlicht in:	Oncogene 2010-01, Vol.29 (3), p.335-344
Hauptverfasser:	Robinson, J P, VanBrocklin, M W, Guilbeault, A R, Signorelli, D L, Brandner, S, Holmen, S L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Astrocytes - cytology Astrocytes - metabolism Avian leukosis virus Biological and medical sciences Blotting, Western Brain cancer Cell Biology Cell Line Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cells, Cultured Cyclin-Dependent Kinase Inhibitor p16 - genetics Cyclin-Dependent Kinase Inhibitor p16 - metabolism Enzyme Activation Fundamental and applied biological sciences. Psychology Gene mutations Genetic aspects Genetics Glioma - genetics Glioma - metabolism Glioma - pathology Gliomas Growth factor receptors Human Genetics Immunohistochemistry Internal Medicine Medical sciences Medicine Medicine & Public Health Mice Mice, Transgenic Mitogen-Activated Protein Kinases - metabolism Molecular and cellular biology Mutation Neurology Oncology original-article Physiological aspects Proto-Oncogene Proteins B-raf - genetics Proto-Oncogene Proteins B-raf - metabolism Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Proto-Oncogene Proteins p21(ras) - genetics Proto-Oncogene Proteins p21(ras) - metabolism Risk factors Rodents Signal transduction Transfection Tumors of the nervous system. Phacomatoses
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