Healing Efficacy of an EGF Impregnated Triple Gel Based Wound Dressing : In Vitro and In Vivo Studies
To accomplish an ideal wound healing process which promotes healthy tissue growth with less scaring, a novel gel based topical drug delivery system composed of 3 different polymers chitosan, dextran sulfate, and polyvinylpyrrolidone K30 (CDP) was prepared. The physicochemical properties of the prepa...
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| Veröffentlicht in: | BioMed research international 2014-01, Vol.2014 (2014), p.1-10 |
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| creator | Khanbanha, Najmeh Atyabi, Fatemeh Taheri, Azade Talaie, Fatemeh Mahbod, Mirgholamreza Dinarvand, Rassoul |
| description | To accomplish an ideal wound healing process which promotes healthy tissue growth with less scaring, a novel gel based topical drug delivery system composed of 3 different polymers chitosan, dextran sulfate, and polyvinylpyrrolidone K30 (CDP) was prepared. The physicochemical properties of the prepared gels were investigated in vitro. Gels showed a maximum swelling ratio of 50 ± 1.95 times of dried gel in PBS at pH 7.4. The swelling ratios increase in acidic and alkaline pH to 55.3 ± 1.75 and 65.5 ± 2.42, respectively. In the rheological test, prepared gels revealed viscoelastic properties and a small linear viscoelastic region of 0.166%. In vivo wound healing promoting activities of CDP gels containing 20 μg/mL EGF were evaluated on surgically induced dermal wounds in rats using pathologic examination. The application of CDP gel with incorporated EGF significantly reduced the defect on the rat’s skin and enhanced epithelial healing compared with the topical application of the EGF-free CDP gel. The results clearly substantiate the beneficial effects of the topical application of CDP containing EGF in the acceleration of healthy wound healing process with less scarring. |
| doi_str_mv | 10.1155/2014/493732 |
| format | Article |
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The physicochemical properties of the prepared gels were investigated in vitro. Gels showed a maximum swelling ratio of 50 ± 1.95 times of dried gel in PBS at pH 7.4. The swelling ratios increase in acidic and alkaline pH to 55.3 ± 1.75 and 65.5 ± 2.42, respectively. In the rheological test, prepared gels revealed viscoelastic properties and a small linear viscoelastic region of 0.166%. In vivo wound healing promoting activities of CDP gels containing 20 μg/mL EGF were evaluated on surgically induced dermal wounds in rats using pathologic examination. The application of CDP gel with incorporated EGF significantly reduced the defect on the rat’s skin and enhanced epithelial healing compared with the topical application of the EGF-free CDP gel. The results clearly substantiate the beneficial effects of the topical application of CDP containing EGF in the acceleration of healthy wound healing process with less scarring.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2014/493732</identifier><identifier>PMID: 25110681</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Puplishing Corporation</publisher><subject>Animals ; Bandages ; Calorimetry, Differential Scanning ; Care and treatment ; Chitosan - chemistry ; Dextrans - chemistry ; Drug delivery systems ; Epidermal growth factor ; Epidermal Growth Factor - pharmacology ; Epithelium - drug effects ; Epithelium - pathology ; Gels - pharmacology ; Healing ; Humans ; Male ; Medical research ; Physiological aspects ; Povidone - chemistry ; Rats, Wistar ; Rheology - drug effects ; Rodents ; Treatment Outcome ; Wound healing ; Wound Healing - drug effects ; Wounds and injuries</subject><ispartof>BioMed research international, 2014-01, Vol.2014 (2014), p.1-10</ispartof><rights>Copyright © 2014 Najmeh Khanbanha et al.</rights><rights>COPYRIGHT 2014 John Wiley & Sons, Inc.</rights><rights>Copyright © 2014 Najmeh Khanbanha et al. Najmeh Khanbanha et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2014 Najmeh Khanbanha et al. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c593t-244c6faba7058eec662344d88a509da0d99eeba25895bd7f4d9af31ea3fdc93</citedby><cites>FETCH-LOGICAL-c593t-244c6faba7058eec662344d88a509da0d99eeba25895bd7f4d9af31ea3fdc93</cites><orcidid>0000-0003-0694-7556</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109371/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109371/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25110681$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Wang, Aijun</contributor><creatorcontrib>Khanbanha, Najmeh</creatorcontrib><creatorcontrib>Atyabi, Fatemeh</creatorcontrib><creatorcontrib>Taheri, Azade</creatorcontrib><creatorcontrib>Talaie, Fatemeh</creatorcontrib><creatorcontrib>Mahbod, Mirgholamreza</creatorcontrib><creatorcontrib>Dinarvand, Rassoul</creatorcontrib><title>Healing Efficacy of an EGF Impregnated Triple Gel Based Wound Dressing : In Vitro and In Vivo Studies</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>To accomplish an ideal wound healing process which promotes healthy tissue growth with less scaring, a novel gel based topical drug delivery system composed of 3 different polymers chitosan, dextran sulfate, and polyvinylpyrrolidone K30 (CDP) was prepared. The physicochemical properties of the prepared gels were investigated in vitro. Gels showed a maximum swelling ratio of 50 ± 1.95 times of dried gel in PBS at pH 7.4. The swelling ratios increase in acidic and alkaline pH to 55.3 ± 1.75 and 65.5 ± 2.42, respectively. In the rheological test, prepared gels revealed viscoelastic properties and a small linear viscoelastic region of 0.166%. In vivo wound healing promoting activities of CDP gels containing 20 μg/mL EGF were evaluated on surgically induced dermal wounds in rats using pathologic examination. The application of CDP gel with incorporated EGF significantly reduced the defect on the rat’s skin and enhanced epithelial healing compared with the topical application of the EGF-free CDP gel. The results clearly substantiate the beneficial effects of the topical application of CDP containing EGF in the acceleration of healthy wound healing process with less scarring.</description><subject>Animals</subject><subject>Bandages</subject><subject>Calorimetry, Differential Scanning</subject><subject>Care and treatment</subject><subject>Chitosan - chemistry</subject><subject>Dextrans - chemistry</subject><subject>Drug delivery systems</subject><subject>Epidermal growth factor</subject><subject>Epidermal Growth Factor - pharmacology</subject><subject>Epithelium - drug effects</subject><subject>Epithelium - pathology</subject><subject>Gels - pharmacology</subject><subject>Healing</subject><subject>Humans</subject><subject>Male</subject><subject>Medical research</subject><subject>Physiological aspects</subject><subject>Povidone - chemistry</subject><subject>Rats, Wistar</subject><subject>Rheology - drug effects</subject><subject>Rodents</subject><subject>Treatment Outcome</subject><subject>Wound healing</subject><subject>Wound Healing - 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The physicochemical properties of the prepared gels were investigated in vitro. Gels showed a maximum swelling ratio of 50 ± 1.95 times of dried gel in PBS at pH 7.4. The swelling ratios increase in acidic and alkaline pH to 55.3 ± 1.75 and 65.5 ± 2.42, respectively. In the rheological test, prepared gels revealed viscoelastic properties and a small linear viscoelastic region of 0.166%. In vivo wound healing promoting activities of CDP gels containing 20 μg/mL EGF were evaluated on surgically induced dermal wounds in rats using pathologic examination. The application of CDP gel with incorporated EGF significantly reduced the defect on the rat’s skin and enhanced epithelial healing compared with the topical application of the EGF-free CDP gel. The results clearly substantiate the beneficial effects of the topical application of CDP containing EGF in the acceleration of healthy wound healing process with less scarring.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Puplishing Corporation</pub><pmid>25110681</pmid><doi>10.1155/2014/493732</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-0694-7556</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Bandages Calorimetry, Differential Scanning Care and treatment Chitosan - chemistry Dextrans - chemistry Drug delivery systems Epidermal growth factor Epidermal Growth Factor - pharmacology Epithelium - drug effects Epithelium - pathology Gels - pharmacology Healing Humans Male Medical research Physiological aspects Povidone - chemistry Rats, Wistar Rheology - drug effects Rodents Treatment Outcome Wound healing Wound Healing - drug effects Wounds and injuries |
| title | Healing Efficacy of an EGF Impregnated Triple Gel Based Wound Dressing : In Vitro and In Vivo Studies |
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