Activation of AMP-activated protein kinase in cerebella of Atm−/− mice is attributable to accumulation of reactive oxygen species

► Upregulation of p-AMPK and ROS coordinately occur in the cerebella of Atm−/− mice. ► Elevation of p-AMPK by H2O2 in primary cerebellar astrocytes is Atm-independent. ► MSL reduces p-AMPK and ROS and corrects the neuromotor deficits in Atm−/− mice. Ataxia telangiectasia (A-T) is an inherited diseas...

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Veröffentlicht in:	Biochemical and biophysical research communications 2012-02, Vol.418 (2), p.267-272
Hauptverfasser:	Kuang, Xianghong, Yan, Mingshan, Ajmo, Joanne M., Scofield, Virginia L., Stoica, George, Wong, Paul K.Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	AMP-Activated Protein Kinases - biosynthesis AMPK Animals Antioxidants - administration & dosage Ataxia Telangiectasia - enzymology Ataxia Telangiectasia - genetics Ataxia Telangiectasia - pathology Ataxia Telangiectasia Mutated Proteins Ataxia-telangiectasia ATM Cell Cycle Proteins - genetics Cerebellum Cerebellum - enzymology Cerebellum - pathology Disease Models, Animal DNA-Binding Proteins - genetics Heredodegenerative Disorders, Nervous System - enzymology Heredodegenerative Disorders, Nervous System - genetics Heredodegenerative Disorders, Nervous System - pathology Luminol - analogs & derivatives Mice Mice, Mutant Strains Mutation Oxidative Stress - drug effects Phthalazines - administration & dosage Protein-Serine-Threonine Kinases - genetics Reactive oxygen species Reactive Oxygen Species - antagonists & inhibitors Reactive Oxygen Species - metabolism Tumor Suppressor Proteins - genetics
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