Influence of Atopic Dermatitis on Reproduction and Uterine Natural Killer Cells
The causal relationship between severe allergic conditions and successful pregnancy remains unclear. We aimed to evaluate reproductive performance in an experimental mouse model of atopic disease (AD), and the appearance of uterine natural killer (uNK) cells that have crucial roles in placental form...
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| Veröffentlicht in: | Journal of Veterinary Medical Science 2014, Vol.76(6), pp.913-916 |
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| creator | HAYASHI, Kazuhiko KUSAKABE, Ken Takeshi SUGIMOTO, Satoko WAKITANI, Shoichi SUGI, Shinji KUNIYOSHI, Nobue HIYAMA, Masato TAKESHITA, Ai KANO, Kiyoshi KISO, Yasuo |
| description | The causal relationship between severe allergic conditions and successful pregnancy remains unclear. We aimed to evaluate reproductive performance in an experimental mouse model of atopic disease (AD), and the appearance of uterine natural killer (uNK) cells that have crucial roles in placental formation was examined. In the NC/Nga pregnant mice with moderate skin allergic lesions and an 8.6-fold elevation of plasma IgE, significant differences were not detected in the reproductive indices of the number of normal fetuses, abortion rate and placental size. There were few uNK cells in the placenta of AD mice, and they showed a significant decrease regarding the immature subtype as compared with controls. These findings revealed that AD disturbs uNK cell differentiation and provides disadvantageous effects on placental formation, although it does not arrest the pregnancy process. It may be possible that specific immunological conditions behind AD operate favorably to recover the reproductive performance. |
| doi_str_mv | 10.1292/jvms.13-0547 |
| format | Article |
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We aimed to evaluate reproductive performance in an experimental mouse model of atopic disease (AD), and the appearance of uterine natural killer (uNK) cells that have crucial roles in placental formation was examined. In the NC/Nga pregnant mice with moderate skin allergic lesions and an 8.6-fold elevation of plasma IgE, significant differences were not detected in the reproductive indices of the number of normal fetuses, abortion rate and placental size. There were few uNK cells in the placenta of AD mice, and they showed a significant decrease regarding the immature subtype as compared with controls. These findings revealed that AD disturbs uNK cell differentiation and provides disadvantageous effects on placental formation, although it does not arrest the pregnancy process. It may be possible that specific immunological conditions behind AD operate favorably to recover the reproductive performance.</description><identifier>ISSN: 0916-7250</identifier><identifier>EISSN: 1347-7439</identifier><identifier>DOI: 10.1292/jvms.13-0547</identifier><identifier>PMID: 24572632</identifier><language>eng</language><publisher>Japan: JAPANESE SOCIETY OF VETERINARY SCIENCE</publisher><subject>Anatomy ; Animals ; atopic disease ; Cell Differentiation - immunology ; Dermatitis, Atopic - immunology ; Female ; Histological Techniques ; Immunoglobulin E - blood ; Killer Cells, Natural - immunology ; Mice ; NC/Nga mouse ; placenta ; Placenta - cytology ; Placenta - immunology ; Placentation ; Pregnancy ; Reproduction - immunology ; uNK cell ; Uterus - cytology ; Uterus - immunology</subject><ispartof>Journal of Veterinary Medical Science, 2014, Vol.76(6), pp.913-916</ispartof><rights>2014 by the Japanese Society of Veterinary Science</rights><rights>Copyright Japan Science and Technology Agency 2014</rights><rights>2014 The Japanese Society of Veterinary Science 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c553t-e4454c1a9c9ca20ea1039a9e197689f604311a90ad4ce6845c47416163459ffd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108779/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108779/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,886,1884,4025,27928,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24572632$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HAYASHI, Kazuhiko</creatorcontrib><creatorcontrib>KUSAKABE, Ken Takeshi</creatorcontrib><creatorcontrib>SUGIMOTO, Satoko</creatorcontrib><creatorcontrib>WAKITANI, Shoichi</creatorcontrib><creatorcontrib>SUGI, Shinji</creatorcontrib><creatorcontrib>KUNIYOSHI, Nobue</creatorcontrib><creatorcontrib>HIYAMA, Masato</creatorcontrib><creatorcontrib>TAKESHITA, Ai</creatorcontrib><creatorcontrib>KANO, Kiyoshi</creatorcontrib><creatorcontrib>KISO, Yasuo</creatorcontrib><title>Influence of Atopic Dermatitis on Reproduction and Uterine Natural Killer Cells</title><title>Journal of Veterinary Medical Science</title><addtitle>J. Vet. Med. Sci.</addtitle><description>The causal relationship between severe allergic conditions and successful pregnancy remains unclear. We aimed to evaluate reproductive performance in an experimental mouse model of atopic disease (AD), and the appearance of uterine natural killer (uNK) cells that have crucial roles in placental formation was examined. In the NC/Nga pregnant mice with moderate skin allergic lesions and an 8.6-fold elevation of plasma IgE, significant differences were not detected in the reproductive indices of the number of normal fetuses, abortion rate and placental size. There were few uNK cells in the placenta of AD mice, and they showed a significant decrease regarding the immature subtype as compared with controls. These findings revealed that AD disturbs uNK cell differentiation and provides disadvantageous effects on placental formation, although it does not arrest the pregnancy process. It may be possible that specific immunological conditions behind AD operate favorably to recover the reproductive performance.</description><subject>Anatomy</subject><subject>Animals</subject><subject>atopic disease</subject><subject>Cell Differentiation - immunology</subject><subject>Dermatitis, Atopic - immunology</subject><subject>Female</subject><subject>Histological Techniques</subject><subject>Immunoglobulin E - blood</subject><subject>Killer Cells, Natural - immunology</subject><subject>Mice</subject><subject>NC/Nga mouse</subject><subject>placenta</subject><subject>Placenta - cytology</subject><subject>Placenta - immunology</subject><subject>Placentation</subject><subject>Pregnancy</subject><subject>Reproduction - immunology</subject><subject>uNK cell</subject><subject>Uterus - cytology</subject><subject>Uterus - immunology</subject><issn>0916-7250</issn><issn>1347-7439</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkU1rFTEUhoMo9lrduZYBNy6cmu9MNkK9fpUWC2LXIWbOtLnMJLdJpuC_b8Z7vdRucgjvw8M5vAi9JviEUE0_bO6mfEJYiwVXT9CKMK5axZl-ilZYE9kqKvARepHzBmNKuNTP0RHlQlHJ6ApdnoVhnCE4aOLQnJa49a75DGmyxRefmxian7BNsZ9d8fVjQ99cFUg-QPPDljnZsTn34wipWcM45pfo2WDHDK_28xhdff3ya_29vbj8drY-vWidEKy0wLngjljttLMUgyWYaauBaCU7PUjMGakptj13IDsuHFecSCIZF3oYenaMPu682_n3BL2DUOoqZpv8ZNMfE603_yfB35jreGc4wZ1Sugre7QUp3s6Qi5l8dvUEGyDO2RDBGe1Ix1VF3z5CN3FOoZ73lyK8-hbh-x3lUsw5wXBYhmCzNGWWpgxhZmmq4m8eHnCA_1VTgU87YJOLvYYDYFPxboSdTUkjl2dvPYTuxiYDgd0Djz2m9w</recordid><startdate>2014</startdate><enddate>2014</enddate><creator>HAYASHI, Kazuhiko</creator><creator>KUSAKABE, Ken Takeshi</creator><creator>SUGIMOTO, Satoko</creator><creator>WAKITANI, Shoichi</creator><creator>SUGI, Shinji</creator><creator>KUNIYOSHI, Nobue</creator><creator>HIYAMA, Masato</creator><creator>TAKESHITA, Ai</creator><creator>KANO, Kiyoshi</creator><creator>KISO, Yasuo</creator><general>JAPANESE SOCIETY OF VETERINARY SCIENCE</general><general>Japan Science and Technology Agency</general><general>The Japanese Society of Veterinary Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QR</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>2014</creationdate><title>Influence of Atopic Dermatitis on Reproduction and Uterine Natural Killer Cells</title><author>HAYASHI, Kazuhiko ; KUSAKABE, Ken Takeshi ; SUGIMOTO, Satoko ; WAKITANI, Shoichi ; SUGI, Shinji ; KUNIYOSHI, Nobue ; HIYAMA, Masato ; TAKESHITA, Ai ; KANO, Kiyoshi ; KISO, Yasuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c553t-e4454c1a9c9ca20ea1039a9e197689f604311a90ad4ce6845c47416163459ffd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Anatomy</topic><topic>Animals</topic><topic>atopic disease</topic><topic>Cell Differentiation - immunology</topic><topic>Dermatitis, Atopic - immunology</topic><topic>Female</topic><topic>Histological Techniques</topic><topic>Immunoglobulin E - blood</topic><topic>Killer Cells, Natural - immunology</topic><topic>Mice</topic><topic>NC/Nga mouse</topic><topic>placenta</topic><topic>Placenta - cytology</topic><topic>Placenta - immunology</topic><topic>Placentation</topic><topic>Pregnancy</topic><topic>Reproduction - immunology</topic><topic>uNK cell</topic><topic>Uterus - cytology</topic><topic>Uterus - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HAYASHI, Kazuhiko</creatorcontrib><creatorcontrib>KUSAKABE, Ken Takeshi</creatorcontrib><creatorcontrib>SUGIMOTO, Satoko</creatorcontrib><creatorcontrib>WAKITANI, Shoichi</creatorcontrib><creatorcontrib>SUGI, Shinji</creatorcontrib><creatorcontrib>KUNIYOSHI, Nobue</creatorcontrib><creatorcontrib>HIYAMA, Masato</creatorcontrib><creatorcontrib>TAKESHITA, Ai</creatorcontrib><creatorcontrib>KANO, Kiyoshi</creatorcontrib><creatorcontrib>KISO, Yasuo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Chemoreception Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of Veterinary Medical Science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HAYASHI, Kazuhiko</au><au>KUSAKABE, Ken Takeshi</au><au>SUGIMOTO, Satoko</au><au>WAKITANI, Shoichi</au><au>SUGI, Shinji</au><au>KUNIYOSHI, Nobue</au><au>HIYAMA, Masato</au><au>TAKESHITA, Ai</au><au>KANO, Kiyoshi</au><au>KISO, Yasuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of Atopic Dermatitis on Reproduction and Uterine Natural Killer Cells</atitle><jtitle>Journal of Veterinary Medical Science</jtitle><addtitle>J. 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| subjects | Anatomy Animals atopic disease Cell Differentiation - immunology Dermatitis, Atopic - immunology Female Histological Techniques Immunoglobulin E - blood Killer Cells, Natural - immunology Mice NC/Nga mouse placenta Placenta - cytology Placenta - immunology Placentation Pregnancy Reproduction - immunology uNK cell Uterus - cytology Uterus - immunology |
| title | Influence of Atopic Dermatitis on Reproduction and Uterine Natural Killer Cells |
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