The adaptor TRAF5 limits the differentiation of inflammatory CD4+ T cells by antagonizing signaling via the receptor for IL-6

Adaptors of the TRAF family are tumor-necrosis factor receptor–associated factors. So and colleagues show that TRAF5 negative regulates the IL-6 receptor signaling pathway, which limits the induction of proinflammatory CD4 + T cells. The physiological functions of members of the tumor-necrosis facto...

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Veröffentlicht in:	Nature immunology 2014-05, Vol.15 (5), p.449-456
Hauptverfasser:	Nagashima, Hiroyuki, Okuyama, Yuko, Asao, Atsuko, Kawabe, Takeshi, Yamaki, Satoshi, Nakano, Hiroyasu, Croft, Michael, Ishii, Naoto, So, Takanori
Format:	Artikel
Sprache:	eng
Schlagworte:	13/109 13/31 13/95 631/250/127/1213 631/250/1619/554/1898/1273 631/250/2152/1566/2493 631/250/516 Animals Biomedicine CD4 Antigens - metabolism Cell Differentiation - genetics Cells, Cultured Cytokine Receptor gp130 - metabolism Disease Progression Encephalomyelitis, Autoimmune, Experimental - immunology Immunology Infectious Diseases Interleukin-6 - immunology Mice Mice, Inbred Strains Mice, Knockout Myelin-Oligodendrocyte Glycoprotein - immunology Peptide Fragments - immunology Physiology Signal Transduction - genetics STAT3 Transcription Factor - metabolism T-Lymphocyte Subsets - immunology Th17 Cells - immunology TNF Receptor-Associated Factor 5 - genetics TNF Receptor-Associated Factor 5 - metabolism Transcriptional Activation - genetics
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