A pause sequence enriched at translation start sites drives transcription dynamics in vivo

Transcription by RNA polymerase (RNAP) is interrupted by pauses that play diverse regulatory roles. Although individual pauses have been studied in vitro, the determinants of pauses in vivo and their distribution throughout the bacterial genome remain unknown. Using nascent transcript sequencing, we...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Science (American Association for the Advancement of Science) 2014-05, Vol.344 (6187), p.1042-1047
Hauptverfasser:	Larson, Matthew H., Mooney, Rachel A., Peters, Jason M., Windgassen, Tricia, Nayak, Dhananjaya, Gross, Carol A., Block, Steven M., Greenleaf, William J., Landick, Robert, Weissman, Jonathan S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Active sites Bacteria Bacteriology Base Sequence Codon, Initiator - genetics Consensus Sequence Deoxyribonucleic acid DNA DNA-directed RNA polymerase DNA-Directed RNA Polymerases - metabolism E coli Earth Escherichia coli Escherichia coli - genetics Escherichia coli - metabolism Folding Gene expression gene expression regulation Gene Expression Regulation, Bacterial Genes Genomes Genomics Molecular biology Nucleotides Operons Peptide Chain Initiation, Translational - genetics Recruitment Regulatory Elements, Transcriptional Ribonucleic acids RNA RNA folding RNA polymerase Scaffolds Start codon transcription (genetics) transcription factors Transcription, Genetic Translation translation (genetics) Translations
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!