Effect of PEG molecular weight on stability, T2 contrast, cytotoxicity, and cellular uptake of superparamagnetic iron oxide nanoparticles (SPIONs)

•SPIONs with various PEG MWs coating for potential atherosclerosis MRI contrast agents.•Optimal condition determined for stability, T2 contrast, cytotoxicity, and cellular uptake.•100ppm Fe SPION with PEG 2K showed the optimal condition for the application.•Cell viability increased when SPIONs were...

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Veröffentlicht in:	Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2014-07, Vol.119, p.106-114
Hauptverfasser:	Park, Yoonjee C., Smith, Jared B., Pham, Tuan, Whitaker, Ragnhild D., Sucato, Christopher A., Hamilton, James A., Bartolak-Suki, Elizabeth, Wong, Joyce Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals atherosclerosis Biological Transport Cattle Cell Survival - drug effects cell viability Cells, Cultured Coated Materials, Biocompatible - chemistry Coated Materials, Biocompatible - pharmacology Coating colloids Contrast Media - chemistry Contrast Media - pharmacology cytotoxicity Ferrosoferric Oxide - chemistry iron iron oxides magnetic resonance imaging Magnetite Nanoparticles - chemistry Molecular Weight Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - metabolism myocytes Myocytes, Smooth Muscle - cytology Myocytes, Smooth Muscle - drug effects Myocytes, Smooth Muscle - metabolism nanoparticles Particle internalization polyethylene glycol Polyethylene Glycols - chemistry smooth muscle Stability Superparamagnetic iron oxide nanoparticles T2 relaxation Toxicity washing
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