Uncovering the role of the insula in non-motor symptoms of Parkinson's disease
Patients with Parkinson's disease experience a range of non-motor symptoms, including cognitive impairment, behavioural changes, somatosensory and autonomic disturbances. The insula, which was once thought to be primarily a limbic cortical structure, is now known to be highly involved in integr...
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| Veröffentlicht in: | Brain (London, England : 1878) England : 1878), 2014-08, Vol.137 (Pt 8), p.2143-2154 |
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| container_issue | Pt 8 |
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| container_title | Brain (London, England : 1878) |
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| creator | CHRISTOPHER, Leigh KOSHIMORI, Yuko LANG, Anthony E CRIAUD, Marion STRAFELLA, Antonio P |
| description | Patients with Parkinson's disease experience a range of non-motor symptoms, including cognitive impairment, behavioural changes, somatosensory and autonomic disturbances. The insula, which was once thought to be primarily a limbic cortical structure, is now known to be highly involved in integrating somatosensory, autonomic and cognitive-affective information to guide behaviour. Thus, it acts as a central hub for processing relevant information related to the state of the body as well as cognitive and mood states. Despite these crucial functions, the insula has been largely overlooked as a potential key region in contributing to non-motor symptoms of Parkinson's disease. The insula is affected in Parkinson's disease by alpha-synuclein deposition, disruptions in normal neurotransmitter function, alterations in connectivity as well as metabolic and structural changes. Although research focusing on the role of the insula in Parkinson's disease is scarce, there is evidence from neuroimaging studies linking the insula to cognitive decline, behavioural abnormalities and somatosensory disturbances. Here, we review imaging studies that provide insight into the potential role of the insula in Parkinson's disease non-motor symptoms. |
| doi_str_mv | 10.1093/brain/awu084 |
| format | Article |
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The insula, which was once thought to be primarily a limbic cortical structure, is now known to be highly involved in integrating somatosensory, autonomic and cognitive-affective information to guide behaviour. Thus, it acts as a central hub for processing relevant information related to the state of the body as well as cognitive and mood states. Despite these crucial functions, the insula has been largely overlooked as a potential key region in contributing to non-motor symptoms of Parkinson's disease. The insula is affected in Parkinson's disease by alpha-synuclein deposition, disruptions in normal neurotransmitter function, alterations in connectivity as well as metabolic and structural changes. Although research focusing on the role of the insula in Parkinson's disease is scarce, there is evidence from neuroimaging studies linking the insula to cognitive decline, behavioural abnormalities and somatosensory disturbances. Here, we review imaging studies that provide insight into the potential role of the insula in Parkinson's disease non-motor symptoms.</description><identifier>ISSN: 0006-8950</identifier><identifier>EISSN: 1460-2156</identifier><identifier>DOI: 10.1093/brain/awu084</identifier><identifier>PMID: 24736308</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Biological and medical sciences ; Cerebral Cortex - metabolism ; Cerebral Cortex - physiopathology ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy ; Humans ; Medical sciences ; Nervous system (semeiology, syndromes) ; Nervous system as a whole ; Neurology ; Parkinson Disease - complications ; Parkinson Disease - physiopathology ; Review</subject><ispartof>Brain (London, England : 1878), 2014-08, Vol.137 (Pt 8), p.2143-2154</ispartof><rights>2015 INIST-CNRS</rights><rights>The Author (2014). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oup.com.</rights><rights>The Author (2014). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oup.com 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c480t-ce0a82767c72a412a5d38162465bf0d5c91af3cfa35b5a8433d56005c29644d13</citedby><cites>FETCH-LOGICAL-c480t-ce0a82767c72a412a5d38162465bf0d5c91af3cfa35b5a8433d56005c29644d13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28608820$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24736308$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CHRISTOPHER, Leigh</creatorcontrib><creatorcontrib>KOSHIMORI, Yuko</creatorcontrib><creatorcontrib>LANG, Anthony E</creatorcontrib><creatorcontrib>CRIAUD, Marion</creatorcontrib><creatorcontrib>STRAFELLA, Antonio P</creatorcontrib><title>Uncovering the role of the insula in non-motor symptoms of Parkinson's disease</title><title>Brain (London, England : 1878)</title><addtitle>Brain</addtitle><description>Patients with Parkinson's disease experience a range of non-motor symptoms, including cognitive impairment, behavioural changes, somatosensory and autonomic disturbances. The insula, which was once thought to be primarily a limbic cortical structure, is now known to be highly involved in integrating somatosensory, autonomic and cognitive-affective information to guide behaviour. Thus, it acts as a central hub for processing relevant information related to the state of the body as well as cognitive and mood states. Despite these crucial functions, the insula has been largely overlooked as a potential key region in contributing to non-motor symptoms of Parkinson's disease. The insula is affected in Parkinson's disease by alpha-synuclein deposition, disruptions in normal neurotransmitter function, alterations in connectivity as well as metabolic and structural changes. Although research focusing on the role of the insula in Parkinson's disease is scarce, there is evidence from neuroimaging studies linking the insula to cognitive decline, behavioural abnormalities and somatosensory disturbances. Here, we review imaging studies that provide insight into the potential role of the insula in Parkinson's disease non-motor symptoms.</description><subject>Biological and medical sciences</subject><subject>Cerebral Cortex - metabolism</subject><subject>Cerebral Cortex - physiopathology</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Nervous system as a whole</subject><subject>Neurology</subject><subject>Parkinson Disease - complications</subject><subject>Parkinson Disease - physiopathology</subject><subject>Review</subject><issn>0006-8950</issn><issn>1460-2156</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpV0c9P2zAUB3ALgUbHdtt5ygWxAxnPP-NekFC1MSS07TDO1qvjFENiFzsp6n9PSguD07Pkj7623peQLxS-U5jys3lCH87wcQAt9siECgUlo1LtkwkAqFJPJRySjznfAVDBmfpADpmouOKgJ-T3TbBx5ZIPi6K_dUWKrSti83z2IQ8tjqMIMZRd7GMq8rpb9rHLG_MX0_1oYjjJRe2zw-w-kYMG2-w-7-YRufn549_sV3n95_JqdnFdWqGhL60D1KxSla0YCspQ1lxTxYSS8wZqaacUG24b5HIuUQvOa6kApGVTJURN-RE53-Yuh3nnautCn7A1y-Q7TGsT0Zv3N8HfmkVcGUGhqjgfA77tAlJ8GFzuTeezdW2LwcUhGyqFVpxyKUZ6uqU2xZyTa16foWA2FZjnCsy2gpF_ffu1V_yy8xEc7wBmi22TMFif_zutQGsG_AlFtpFc</recordid><startdate>20140801</startdate><enddate>20140801</enddate><creator>CHRISTOPHER, Leigh</creator><creator>KOSHIMORI, Yuko</creator><creator>LANG, Anthony E</creator><creator>CRIAUD, Marion</creator><creator>STRAFELLA, Antonio P</creator><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20140801</creationdate><title>Uncovering the role of the insula in non-motor symptoms of Parkinson's disease</title><author>CHRISTOPHER, Leigh ; KOSHIMORI, Yuko ; LANG, Anthony E ; CRIAUD, Marion ; STRAFELLA, Antonio P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c480t-ce0a82767c72a412a5d38162465bf0d5c91af3cfa35b5a8433d56005c29644d13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Biological and medical sciences</topic><topic>Cerebral Cortex - metabolism</topic><topic>Cerebral Cortex - physiopathology</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Nervous system as a whole</topic><topic>Neurology</topic><topic>Parkinson Disease - complications</topic><topic>Parkinson Disease - physiopathology</topic><topic>Review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CHRISTOPHER, Leigh</creatorcontrib><creatorcontrib>KOSHIMORI, Yuko</creatorcontrib><creatorcontrib>LANG, Anthony E</creatorcontrib><creatorcontrib>CRIAUD, Marion</creatorcontrib><creatorcontrib>STRAFELLA, Antonio P</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Brain (London, England : 1878)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CHRISTOPHER, Leigh</au><au>KOSHIMORI, Yuko</au><au>LANG, Anthony E</au><au>CRIAUD, Marion</au><au>STRAFELLA, Antonio P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Uncovering the role of the insula in non-motor symptoms of Parkinson's disease</atitle><jtitle>Brain (London, England : 1878)</jtitle><addtitle>Brain</addtitle><date>2014-08-01</date><risdate>2014</risdate><volume>137</volume><issue>Pt 8</issue><spage>2143</spage><epage>2154</epage><pages>2143-2154</pages><issn>0006-8950</issn><eissn>1460-2156</eissn><abstract>Patients with Parkinson's disease experience a range of non-motor symptoms, including cognitive impairment, behavioural changes, somatosensory and autonomic disturbances. The insula, which was once thought to be primarily a limbic cortical structure, is now known to be highly involved in integrating somatosensory, autonomic and cognitive-affective information to guide behaviour. Thus, it acts as a central hub for processing relevant information related to the state of the body as well as cognitive and mood states. Despite these crucial functions, the insula has been largely overlooked as a potential key region in contributing to non-motor symptoms of Parkinson's disease. The insula is affected in Parkinson's disease by alpha-synuclein deposition, disruptions in normal neurotransmitter function, alterations in connectivity as well as metabolic and structural changes. Although research focusing on the role of the insula in Parkinson's disease is scarce, there is evidence from neuroimaging studies linking the insula to cognitive decline, behavioural abnormalities and somatosensory disturbances. Here, we review imaging studies that provide insight into the potential role of the insula in Parkinson's disease non-motor symptoms.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>24736308</pmid><doi>10.1093/brain/awu084</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Brain (London, England : 1878), 2014-08, Vol.137 (Pt 8), p.2143-2154 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Biological and medical sciences Cerebral Cortex - metabolism Cerebral Cortex - physiopathology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Humans Medical sciences Nervous system (semeiology, syndromes) Nervous system as a whole Neurology Parkinson Disease - complications Parkinson Disease - physiopathology Review |
| title | Uncovering the role of the insula in non-motor symptoms of Parkinson's disease |
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