BET Inhibitor JQ1 Blocks Inflammation and Bone Destruction

BET proteins are a group of epigenetic regulators controlling transcription through reading acetylated histone tails and recruiting transcription complexes. They are considered as potential therapeutic targets in many distinct diseases. A novel synthetic bromodomain and extraterminal domain (BET) in...

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Veröffentlicht in:	Journal of dental research 2014-07, Vol.93 (7), p.657-662
Hauptverfasser:	Meng, S., Zhang, L., Tang, Y., Tu, Q., Zheng, L., Yu, L., Murray, D., Cheng, J., Kim, S.H., Zhou, X., Chen, J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid phosphatase (tartrate-resistant) Acid Phosphatase - drug effects Alveolar bone Alveolar Bone Loss - prevention & control Animals Bacteria Bone loss c-Fos protein Calcineurin Cathepsin K Cathepsin K - drug effects Cell Differentiation Cell Line Chromatin Cytokines Disease Epigenetics Gene expression Gum disease Immunoprecipitation Inflammation Inflammatory diseases Interleukin 6 Interleukin-1beta - drug effects Isoenzymes - drug effects Laboratories Lipopolysaccharides Lipopolysaccharides - adverse effects Lymphocytes B Medical research Mice NF-kappa B - drug effects NF-κB protein NFATC Transcription Factors - drug effects Nuclear Proteins - therapeutic use Nuclear transport Osteoclasts Osteoclasts - drug effects Periodontitis Periodontitis - prevention & control Phosphorylation Polymerase chain reaction Promoter Regions, Genetic - drug effects Proteins Proto-Oncogene Proteins c-ets - drug effects Proto-Oncogene Proteins c-fos - drug effects RANK Ligand - drug effects Research Reports RNA polymerase Tartrate-Resistant Acid Phosphatase Therapeutic applications TLR2 protein Toll-Like Receptor 2 - antagonists & inhibitors Toll-Like Receptor 4 - antagonists & inhibitors Toll-like receptors TRANCE protein Transcription Transcription Factor AP-1 - drug effects Transcription Factors - therapeutic use Tumor Necrosis Factor-alpha - drug effects Tumor necrosis factor-TNF Tumor necrosis factor-α
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