Blind prediction performance of RosettaAntibody 3.0: Grafting, relaxation, kinematic loop modeling, and full CDR optimization

ABSTRACT Antibody Modeling Assessment II (AMA‐II) provided an opportunity to benchmark RosettaAntibody on a set of 11 unpublished antibody structures. RosettaAntibody produced accurate, physically realistic models, with all framework regions and 42 of the 55 non‐H3 CDR loops predicted to under an Ån...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Proteins, structure, function, and bioinformatics structure, function, and bioinformatics, 2014-08, Vol.82 (8), p.1611-1623
Hauptverfasser:	Weitzner, Brian D., Kuroda, Daisuke, Marze, Nicholas, Xu, Jianqing, Gray, Jeffrey J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Animals antigen-binding site Biomechanical Phenomena canonical structures Complementarity Determining Regions - chemistry homology modeling Humans immunoglobulin Immunoglobulin Heavy Chains - chemistry Immunoglobulin Light Chains - chemistry Immunoglobulins - chemistry loop prediction Models, Molecular Protein Conformation Rosetta Software
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!