Inflammatory Pain May Induce Cognitive Impairment Through an Interlukin-6-Dependent and Postsynaptic Density-95-Associated Mechanism

BACKGROUND:Pain might be associated with cognitive impairment in humans. However, the characterization of such effects in a preclinical model and the investigation of the underlying mechanisms remain largely to be determined. We therefore sought to establish a system to determine the effect of pain...

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Veröffentlicht in:	Anesthesia and analgesia 2014-08, Vol.119 (2), p.471-480
Hauptverfasser:	Yang, Longqiu, Xin, Xin, Zhang, Jie, Zhang, Lei, Dong, Yuanlin, Zhang, Yiying, Mao, Jianren, Xie, Zhongcong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Behavior, Animal Cerebral Cortex - metabolism Cognition Cognition Disorders - etiology Cognition Disorders - genetics Cognition Disorders - metabolism Cognition Disorders - psychology Conditioning (Psychology) Disease Models, Animal Disks Large Homolog 4 Protein Fear Freund's Adjuvant Guanylate Kinases - metabolism Hippocampus - metabolism Inflammation - chemically induced Inflammation - genetics Inflammation - metabolism Inflammation - psychology Interleukin-6 - deficiency Interleukin-6 - genetics Interleukin-6 - metabolism Membrane Proteins - metabolism Memory Mice Mice, Inbred C57BL Mice, Knockout Pain - etiology Pain - genetics Pain - metabolism Pain - psychology Pain Threshold Signal Transduction Time Factors
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