Zinc finger protein 185 is a liver metastasis-associated factor in colon cancer patients
LIM domain proteins are involved in several fundamental biological processes, including cell lineage specification, cytoskeleton organization and organ development. Zinc finger protein 185 (ZNF185) is one of the LIM domain proteins considered to be involved in the regulation of cellular differentiat...
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| Veröffentlicht in: | Molecular and clinical oncology 2014-09, Vol.2 (5), p.709-713 |
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| creator | FURUKAWA, DAISUKE CHIJIWA, TSUYOSHI MATSUYAMA, MASAHIRO MUKAI, MASAYA MATSUO, EI-ICHI NISHIMURA, OSAMU KAWAI, KENJI SUEMIZU, HIROSHI HIRAOKA, NOBUYOSHI NAKAGOHRI, TOSHIO YASUDA, SEIEI NAKAMURA, MASATO |
| description | LIM domain proteins are involved in several fundamental biological processes, including cell lineage specification, cytoskeleton organization and organ development. Zinc finger protein 185 (ZNF185) is one of the LIM domain proteins considered to be involved in the regulation of cellular differentiation and/or proliferation. However, the detailed functions and properties of ZNF185 in the multistep process of cancer biology have not yet been elucidated. In this study, we analyzed the association between ZNF185 and the clinicopathological characteristics of colon cancer, such as patient age and gender, histological type, lymphatic and venous involvement, T and N status, liver metastasis and stage. ZNF185 protein expression was immunohistochemically analyzed and ZNF185 was detected in the cancer cells of 78 of the 87 colon cancer patients. The correlation between ZNF185 and histological type was significant (P=0.010, G-test). ZNF185 expression was also significantly correlated with liver metastasis (P=0.030, G-test). A multivariate analysis using the Cox proportional hazards model was performed among cause-specific survival rate, ZNF185 expression and clinicopathological characteristics. Histological type, liver metastasis and ZNF185 expression were found to be independent prognostic indicators (P=0.028, P |
| doi_str_mv | 10.3892/mco.2014.298 |
| format | Article |
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Zinc finger protein 185 (ZNF185) is one of the LIM domain proteins considered to be involved in the regulation of cellular differentiation and/or proliferation. However, the detailed functions and properties of ZNF185 in the multistep process of cancer biology have not yet been elucidated. In this study, we analyzed the association between ZNF185 and the clinicopathological characteristics of colon cancer, such as patient age and gender, histological type, lymphatic and venous involvement, T and N status, liver metastasis and stage. ZNF185 protein expression was immunohistochemically analyzed and ZNF185 was detected in the cancer cells of 78 of the 87 colon cancer patients. The correlation between ZNF185 and histological type was significant (P=0.010, G-test). ZNF185 expression was also significantly correlated with liver metastasis (P=0.030, G-test). A multivariate analysis using the Cox proportional hazards model was performed among cause-specific survival rate, ZNF185 expression and clinicopathological characteristics. Histological type, liver metastasis and ZNF185 expression were found to be independent prognostic indicators (P=0.028, P<0.0001 and P=0.036, respectively). Therefore, ZNF185 expression was found to be an independent indicator of liver metastasis and prognosis in patients with colon cancer.</description><identifier>ISSN: 2049-9450</identifier><identifier>EISSN: 2049-9469</identifier><identifier>DOI: 10.3892/mco.2014.298</identifier><identifier>PMID: 25054034</identifier><language>eng</language><publisher>England: D.A. Spandidos</publisher><subject>Colon cancer ; Colorectal cancer ; Complications and side effects ; Deoxyribonucleic acid ; Development and progression ; DNA ; Genetic aspects ; Immunoglobulins ; Liver ; Liver diseases ; liver metastasis ; Medical prognosis ; Metastasis ; Oncology ; Pancreatic cancer ; prognosis ; Properties ; Prostate ; Proteins ; RNA polymerase ; Studies ; zinc finger protein 185 ; Zinc finger proteins</subject><ispartof>Molecular and clinical oncology, 2014-09, Vol.2 (5), p.709-713</ispartof><rights>Copyright © 2014, Spandidos Publications</rights><rights>COPYRIGHT 2014 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2014</rights><rights>Copyright © 2014, Spandidos Publications 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c507t-638c61f142b25e30b676c40daac28fa2559c5707bc7b74b9dd13e50afb3cc223</citedby><cites>FETCH-LOGICAL-c507t-638c61f142b25e30b676c40daac28fa2559c5707bc7b74b9dd13e50afb3cc223</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4106664/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4106664/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,5556,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25054034$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>FURUKAWA, DAISUKE</creatorcontrib><creatorcontrib>CHIJIWA, TSUYOSHI</creatorcontrib><creatorcontrib>MATSUYAMA, MASAHIRO</creatorcontrib><creatorcontrib>MUKAI, MASAYA</creatorcontrib><creatorcontrib>MATSUO, EI-ICHI</creatorcontrib><creatorcontrib>NISHIMURA, OSAMU</creatorcontrib><creatorcontrib>KAWAI, KENJI</creatorcontrib><creatorcontrib>SUEMIZU, HIROSHI</creatorcontrib><creatorcontrib>HIRAOKA, NOBUYOSHI</creatorcontrib><creatorcontrib>NAKAGOHRI, TOSHIO</creatorcontrib><creatorcontrib>YASUDA, SEIEI</creatorcontrib><creatorcontrib>NAKAMURA, MASATO</creatorcontrib><title>Zinc finger protein 185 is a liver metastasis-associated factor in colon cancer patients</title><title>Molecular and clinical oncology</title><addtitle>Mol Clin Oncol</addtitle><description>LIM domain proteins are involved in several fundamental biological processes, including cell lineage specification, cytoskeleton organization and organ development. Zinc finger protein 185 (ZNF185) is one of the LIM domain proteins considered to be involved in the regulation of cellular differentiation and/or proliferation. However, the detailed functions and properties of ZNF185 in the multistep process of cancer biology have not yet been elucidated. In this study, we analyzed the association between ZNF185 and the clinicopathological characteristics of colon cancer, such as patient age and gender, histological type, lymphatic and venous involvement, T and N status, liver metastasis and stage. ZNF185 protein expression was immunohistochemically analyzed and ZNF185 was detected in the cancer cells of 78 of the 87 colon cancer patients. The correlation between ZNF185 and histological type was significant (P=0.010, G-test). ZNF185 expression was also significantly correlated with liver metastasis (P=0.030, G-test). A multivariate analysis using the Cox proportional hazards model was performed among cause-specific survival rate, ZNF185 expression and clinicopathological characteristics. Histological type, liver metastasis and ZNF185 expression were found to be independent prognostic indicators (P=0.028, P<0.0001 and P=0.036, respectively). Therefore, ZNF185 expression was found to be an independent indicator of liver metastasis and prognosis in patients with colon cancer.</description><subject>Colon cancer</subject><subject>Colorectal cancer</subject><subject>Complications and side effects</subject><subject>Deoxyribonucleic acid</subject><subject>Development and progression</subject><subject>DNA</subject><subject>Genetic aspects</subject><subject>Immunoglobulins</subject><subject>Liver</subject><subject>Liver diseases</subject><subject>liver metastasis</subject><subject>Medical prognosis</subject><subject>Metastasis</subject><subject>Oncology</subject><subject>Pancreatic cancer</subject><subject>prognosis</subject><subject>Properties</subject><subject>Prostate</subject><subject>Proteins</subject><subject>RNA polymerase</subject><subject>Studies</subject><subject>zinc finger protein 185</subject><subject>Zinc finger proteins</subject><issn>2049-9450</issn><issn>2049-9469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNptks9rFTEQxxdRbKm9eZYFD3pwn5Pfm4tQir-g4KUH8RKys9masps8k30F_3vn8erTiklIwuQz32Em0zTPGWxEb_nbBfOGA5MbbvtHzSkHaTsrtX18vCs4ac5rvQUa1gBX9mlzwhUoCUKeNl-_xYTtFNNNKO225DXE1LJetbG2vp3jHZmXsPpKK9bO15ox-jWM7eRxzaUlHPOcafcJ9xp-jSGt9VnzZPJzDef351lz_eH99eWn7urLx8-XF1cdKjBrp0WPmk1M8oGrIGDQRqOE0Xvk_eS5UhaVATOgGYwc7DgyERT4aRCInIuz5t1BdrsbljAihS5-dtsSF19-uuyje_iS4nd3k--cZKC1liTw-l6g5B-7UFe3xIphnn0KeVcd67lWVlNRCX35D3qbdyVRdo5ZwaWSRrM_1I2fg4tpyhQX96LuQvQKtAHoidr8h6I5hiViTmGKZH_g8ObggCXXWsJ0zJGB2_eCo15w-15w1AuEv_i7Lkf4988T8OoA1K1PYxxzPTIk1AHvQHVgwIpfrW269Q</recordid><startdate>20140901</startdate><enddate>20140901</enddate><creator>FURUKAWA, DAISUKE</creator><creator>CHIJIWA, TSUYOSHI</creator><creator>MATSUYAMA, MASAHIRO</creator><creator>MUKAI, MASAYA</creator><creator>MATSUO, EI-ICHI</creator><creator>NISHIMURA, OSAMU</creator><creator>KAWAI, KENJI</creator><creator>SUEMIZU, HIROSHI</creator><creator>HIRAOKA, NOBUYOSHI</creator><creator>NAKAGOHRI, TOSHIO</creator><creator>YASUDA, SEIEI</creator><creator>NAKAMURA, MASATO</creator><general>D.A. 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Zinc finger protein 185 (ZNF185) is one of the LIM domain proteins considered to be involved in the regulation of cellular differentiation and/or proliferation. However, the detailed functions and properties of ZNF185 in the multistep process of cancer biology have not yet been elucidated. In this study, we analyzed the association between ZNF185 and the clinicopathological characteristics of colon cancer, such as patient age and gender, histological type, lymphatic and venous involvement, T and N status, liver metastasis and stage. ZNF185 protein expression was immunohistochemically analyzed and ZNF185 was detected in the cancer cells of 78 of the 87 colon cancer patients. The correlation between ZNF185 and histological type was significant (P=0.010, G-test). ZNF185 expression was also significantly correlated with liver metastasis (P=0.030, G-test). A multivariate analysis using the Cox proportional hazards model was performed among cause-specific survival rate, ZNF185 expression and clinicopathological characteristics. Histological type, liver metastasis and ZNF185 expression were found to be independent prognostic indicators (P=0.028, P<0.0001 and P=0.036, respectively). Therefore, ZNF185 expression was found to be an independent indicator of liver metastasis and prognosis in patients with colon cancer.</abstract><cop>England</cop><pub>D.A. Spandidos</pub><pmid>25054034</pmid><doi>10.3892/mco.2014.298</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | Spandidos Publications Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Colon cancer Colorectal cancer Complications and side effects Deoxyribonucleic acid Development and progression DNA Genetic aspects Immunoglobulins Liver Liver diseases liver metastasis Medical prognosis Metastasis Oncology Pancreatic cancer prognosis Properties Prostate Proteins RNA polymerase Studies zinc finger protein 185 Zinc finger proteins |
| title | Zinc finger protein 185 is a liver metastasis-associated factor in colon cancer patients |
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