Evaluation of D2 and D3 dopamine receptor selective compounds on l-dopa-dependent abnormal involuntary movements in rats

A panel of novel D2 and D3 dopamine receptor selective antagonists, partial agonists and full agonists have been evaluated for the ability to attenuate l-dopa-associated abnormal involuntary movements (AIMs) in 6-hydroxydopamine (6-OHDA) unilaterally lesioned male Sprague Dawley rats, which is an an...

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Veröffentlicht in:	Neuropharmacology 2009-05, Vol.56 (6), p.956-969
Hauptverfasser:	Kumar, Rakesh, Riddle, Lindsay R., Griffin, Suzy A., Chu, Wenhua, Vangveravong, Suwanna, Neisewander, Janet, Mach, Robert H., Luedtke, Robert R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylyl Cyclase Inhibitors Animals Antiparkinson Agents - adverse effects Cell Line D3 dopamine receptors Dopamine D2 Receptor Antagonists Dopamine receptors Drug Partial Agonism Dyskinesia Dyskinesia, Drug-Induced - drug therapy Dyskinesia, Drug-Induced - etiology Dyskinesia, Drug-Induced - physiopathology Humans l-dopa Levodopa - adverse effects Male Motor Activity - drug effects Oxidopamine Parkinson's Disease Rats Rats, Sprague-Dawley Receptors, Dopamine D2 - agonists Receptors, Dopamine D3 - agonists Receptors, Dopamine D3 - antagonists & inhibitors
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