Role of 6-O-Sulfated Heparan Sulfate in Chronic Renal Fibrosis

Heparan sulfate (HS) plays a crucial role in the fibrosis associated with chronic allograft dysfunction by binding and presenting cytokines and growth factors to their receptors. These interactions critically depend on the distribution of 6-O-sulfated glucosamine residues, which is generated by gluc...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of biological chemistry 2014-07, Vol.289 (29), p.20295-20306
Hauptverfasser:	Alhasan, Abd A., Spielhofer, Julia, Kusche-Gullberg, Marion, Kirby, John A., Ali, Simi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chronic Disease Disease Models, Animal Fibroblast Growth Factor (FGF) Fibroblast Growth Factor 2 - metabolism Fibrosis Glycobiology and Extracellular Matrices Graft Rejection - metabolism Graft Rejection - pathology Heparan Sulfate Heparitin Sulfate - chemistry Heparitin Sulfate - metabolism Humans Kidney - metabolism Kidney - pathology Kidney Transplantation - adverse effects Male Mice Mice, Inbred C57BL Recombinant Proteins - genetics Recombinant Proteins - metabolism Signal Transduction Sulfatases Sulfates - chemistry Sulfotransferase Sulfotransferases - genetics Sulfotransferases - metabolism Transplantation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!