Lactate Storm Marks Cerebral Metabolism following Brain Trauma

Brain metabolism is thought to be maintained by neuronal-glial metabolic coupling. Glia take up glutamate from the synaptic cleft for conversion into glutamine, triggering glial glycolysis and lactate production. This lactate is shuttled into neurons and further metabolized. The origin and role of l...

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Veröffentlicht in:	The Journal of biological chemistry 2014-07, Vol.289 (29), p.20200-20208
Hauptverfasser:	Lama, Sanju, Auer, Roland N., Tyson, Randy, Gallagher, Clare N., Tomanek, Boguslaw, Sutherland, Garnette R.
Format:	Artikel
Sprache:	eng
Schlagworte:	13C-Labeled Substrates Acetic Acid - metabolism Animals Astrocytes - metabolism Brain - metabolism Brain - pathology Brain Injuries - metabolism Brain Injuries - pathology Brain Injuries - therapy Glial Cell Glial Fibrillary Acidic Protein - metabolism Glucose - metabolism Glycolysis Lactate Lactic Acid - metabolism Magnetic Resonance Spectroscopy Male Metabolism MR Spectroscopy Neuron Neuronal-Glial Metabolism Neurons - metabolism Rats Rats, Sprague-Dawley Tau Protein (Tau) Traumatic Brain Injury Tricarboxylic Acid Cycle (TCA Cycle) (Krebs Cycle)
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