CD8+ T-cell responses rapidly select for antigen-negative tumor cells in the prostate

Stimulation of patients' immune systems for the treatment of solid tumors is an emerging therapeutic paradigm. The use of enriched autologous T cells for adoptive cell therapy or vaccination with antigen-loaded dendritic cells have shown clinical efficacy in melanoma and prostate cancer, respec...

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Veröffentlicht in:	Cancer immunology research 2013-12, Vol.1 (6), p.393-401
Hauptverfasser:	Bak, S Peter, Barnkob, Mike Stein, Wittrup, K Dane, Chen, Jianzhu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Neoplasm - metabolism CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - transplantation Disease Models, Animal Disease Progression Histocompatibility Antigens Class I - metabolism Immunotherapy, Adoptive - methods Lymphocytes, Tumor-Infiltrating - immunology Male Mice, Transgenic Prostatic Neoplasms - immunology Prostatic Neoplasms - pathology Prostatic Neoplasms - therapy
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