Inactivation of Yeast Isw2 Chromatin Remodeling Enzyme Mimics Longevity Effect of Calorie Restriction via Induction of Genotoxic Stress Response

ATP-dependent chromatin remodeling is involved in all DNA transactions and is linked to numerous human diseases. We explored functions of chromatin remodelers during cellular aging. Deletion of ISW2, or mutations inactivating the Isw2 enzyme complex, extends yeast replicative lifespan. This extensio...

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Veröffentlicht in:	Cell metabolism 2014-06, Vol.19 (6), p.952-966
Hauptverfasser:	Dang, Weiwei, Sutphin, George L., Dorsey, Jean A., Otte, Gabriel L., Cao, Kajia, Perry, Rocco M., Wanat, Jennifer J., Saviolaki, Dimitra, Murakami, Christopher J., Tsuchiyama, Scott, Robison, Brett, Gregory, Brian D., Vermeulen, Michiel, Shiekhattar, Ramin, Johnson, F. Brad, Kennedy, Brian K., Kaeberlein, Matt, Berger, Shelley L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases - antagonists & inhibitors Adenosine Triphosphatases - genetics Animals Caenorhabditis elegans - metabolism Caenorhabditis elegans Proteins - genetics Caloric Restriction Cellular Senescence - physiology Chromatin Assembly and Disassembly - physiology DNA Damage DNA Repair - physiology Gene Expression Profiling Gene Expression Regulation, Fungal Gene Knockout Techniques Longevity Peroxidases - biosynthesis Rad51 Recombinase - biosynthesis Rad51 Recombinase - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - antagonists & inhibitors Saccharomyces cerevisiae Proteins - biosynthesis Saccharomyces cerevisiae Proteins - genetics Stress, Physiological Transcription Factors - antagonists & inhibitors Transcription Factors - genetics
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