Scaffold Ranking and Positional Scanning Utilized in the Discovery of nAChR-Selective Compounds Suitable for Optimization Studies

Nicotine binds to nicotinic acetylcholine receptors (nAChR), which can exist as many different subtypes. The α4β2 nAChR is the most prevalent subtype in the brain and possesses the most evidence linking it to nicotine seeking behavior. Herein we report the use of mixture based combinatorial librarie...

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Veröffentlicht in:	Journal of medicinal chemistry 2013-12, Vol.56 (24), p.10103-10117
Hauptverfasser:	Wu, Jinhua, Zhang, Yaohong, Maida, Laura E, Santos, Radleigh G, Welmaker, Gregory S, LaVoi, Travis M, Nefzi, Adel, Yu, Yongping, Houghten, Richard A, Toll, Lawrence, Giulianotti, Marc A
Format:	Artikel
Sprache:	eng
Schlagworte:	Cells, Cultured Dose-Response Relationship, Drug Drug Discovery Humans Molecular Structure Receptors, Nicotinic - chemistry Receptors, Nicotinic - metabolism Small Molecule Libraries - chemistry Small Molecule Libraries - pharmacology Structure-Activity Relationship
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