An updated meta-analysis: apolipoprotein E genotypes and risk of primary open-angle glaucoma
To study the association of apolipoprotein E (APOE) polymorphisms and primary open-angle glaucoma (POAG). After a systematic literature search, all relevant studies evaluating the association between APOE polymorphisms and POAG were included. All statistical tests were calculated with Stata 11.0. Tw...
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| Veröffentlicht in: | Molecular vision 2014-07, Vol.20, p.1025-1036 |
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| creator | Liao, Rongfeng Ye, Minjie Xu, Xiping |
| description | To study the association of apolipoprotein E (APOE) polymorphisms and primary open-angle glaucoma (POAG).
After a systematic literature search, all relevant studies evaluating the association between APOE polymorphisms and POAG were included. All statistical tests were calculated with Stata 11.0.
Twelve independent studies on the APOE gene (1,971 cases, 1,756 controls) and POAG were included. A significant association between the APOE gene and POAG was found in the genetic model of ε4/ε4 versus ε3/ε3 (odds ratio [OR] = 2.09, 95% confidence interval [CI] = 1.12-3.88, p = 0.02). However, no association was detected in the models of ε2/ε2 versus ε3/ε3, ε2/ε3 versus ε3/ε3, ε2/ε4 versus ε3/ε3, ε3/ε4 versus ε3/ε3, allele ε2 versus allele ε3, and allele ε4 versus allele ε3. Subgroup analyses showed that a statistically significant association between the APOE gene and the risk of POAG existed in the genetic model of ε4/ε4 versus ε3/ε3 in Asians (OR = 3.55, 95% CI = 1.06-11.87, p = 0.04). No association was identified between the APOE gene and the risk of POAG in Caucasians.
The present meta-analysis indicated that the ε4/ε4 genotype is associated with increased risk of POAG in Asians. |
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After a systematic literature search, all relevant studies evaluating the association between APOE polymorphisms and POAG were included. All statistical tests were calculated with Stata 11.0.
Twelve independent studies on the APOE gene (1,971 cases, 1,756 controls) and POAG were included. A significant association between the APOE gene and POAG was found in the genetic model of ε4/ε4 versus ε3/ε3 (odds ratio [OR] = 2.09, 95% confidence interval [CI] = 1.12-3.88, p = 0.02). However, no association was detected in the models of ε2/ε2 versus ε3/ε3, ε2/ε3 versus ε3/ε3, ε2/ε4 versus ε3/ε3, ε3/ε4 versus ε3/ε3, allele ε2 versus allele ε3, and allele ε4 versus allele ε3. Subgroup analyses showed that a statistically significant association between the APOE gene and the risk of POAG existed in the genetic model of ε4/ε4 versus ε3/ε3 in Asians (OR = 3.55, 95% CI = 1.06-11.87, p = 0.04). No association was identified between the APOE gene and the risk of POAG in Caucasians.
The present meta-analysis indicated that the ε4/ε4 genotype is associated with increased risk of POAG in Asians.</description><identifier>EISSN: 1090-0535</identifier><identifier>PMID: 25053873</identifier><language>eng</language><publisher>United States: Molecular Vision</publisher><subject>Apolipoproteins E - genetics ; Genetic Predisposition to Disease ; Glaucoma, Open-Angle - ethnology ; Glaucoma, Open-Angle - genetics ; Humans ; Models, Genetic ; Polymorphism, Genetic ; Publication Bias ; Risk Factors</subject><ispartof>Molecular vision, 2014-07, Vol.20, p.1025-1036</ispartof><rights>Copyright © 2014 Molecular Vision. 2014 Molecular Vision</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4105115/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4105115/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25053873$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liao, Rongfeng</creatorcontrib><creatorcontrib>Ye, Minjie</creatorcontrib><creatorcontrib>Xu, Xiping</creatorcontrib><title>An updated meta-analysis: apolipoprotein E genotypes and risk of primary open-angle glaucoma</title><title>Molecular vision</title><addtitle>Mol Vis</addtitle><description>To study the association of apolipoprotein E (APOE) polymorphisms and primary open-angle glaucoma (POAG).
After a systematic literature search, all relevant studies evaluating the association between APOE polymorphisms and POAG were included. All statistical tests were calculated with Stata 11.0.
Twelve independent studies on the APOE gene (1,971 cases, 1,756 controls) and POAG were included. A significant association between the APOE gene and POAG was found in the genetic model of ε4/ε4 versus ε3/ε3 (odds ratio [OR] = 2.09, 95% confidence interval [CI] = 1.12-3.88, p = 0.02). However, no association was detected in the models of ε2/ε2 versus ε3/ε3, ε2/ε3 versus ε3/ε3, ε2/ε4 versus ε3/ε3, ε3/ε4 versus ε3/ε3, allele ε2 versus allele ε3, and allele ε4 versus allele ε3. Subgroup analyses showed that a statistically significant association between the APOE gene and the risk of POAG existed in the genetic model of ε4/ε4 versus ε3/ε3 in Asians (OR = 3.55, 95% CI = 1.06-11.87, p = 0.04). No association was identified between the APOE gene and the risk of POAG in Caucasians.
The present meta-analysis indicated that the ε4/ε4 genotype is associated with increased risk of POAG in Asians.</description><subject>Apolipoproteins E - genetics</subject><subject>Genetic Predisposition to Disease</subject><subject>Glaucoma, Open-Angle - ethnology</subject><subject>Glaucoma, Open-Angle - genetics</subject><subject>Humans</subject><subject>Models, Genetic</subject><subject>Polymorphism, Genetic</subject><subject>Publication Bias</subject><subject>Risk Factors</subject><issn>1090-0535</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkN9KwzAYxYMgbk5fQfIChfxZ0tYLYYypg4E3eieUr8m3Gm2T0LRC396CU_TqwDmcH4dzRpaclSxjSqoFuUzpnTHB1Tq_IAuhZrfI5ZK8bjwdo4UBLe1wgAw8tFNy6ZZCDK2LIfZhQOfpjjbowzBFTBS8pb1LHzQcaexdB_1EQ0Q_t5sWadPCaEIHV-T8CG3C65OuyMv97nn7mB2eHvbbzSGLQsohq8uiRgOiwDyHujaWC5sXtZRCKo1acb4WQnMmC6nAGgNaMZZrrU0pS1MwuSJ339w41h1ag37ooa1Oy6oArvqfePdWNeGzWnM209UMuPkL-G3-_CS_ADYRZVM</recordid><startdate>20140719</startdate><enddate>20140719</enddate><creator>Liao, Rongfeng</creator><creator>Ye, Minjie</creator><creator>Xu, Xiping</creator><general>Molecular Vision</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>5PM</scope></search><sort><creationdate>20140719</creationdate><title>An updated meta-analysis: apolipoprotein E genotypes and risk of primary open-angle glaucoma</title><author>Liao, Rongfeng ; Ye, Minjie ; Xu, Xiping</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p233t-b98beca28e77abbcd12d78b332356e65114226103835adcca65007666c939c803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Apolipoproteins E - genetics</topic><topic>Genetic Predisposition to Disease</topic><topic>Glaucoma, Open-Angle - ethnology</topic><topic>Glaucoma, Open-Angle - genetics</topic><topic>Humans</topic><topic>Models, Genetic</topic><topic>Polymorphism, Genetic</topic><topic>Publication Bias</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liao, Rongfeng</creatorcontrib><creatorcontrib>Ye, Minjie</creatorcontrib><creatorcontrib>Xu, Xiping</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Molecular vision</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liao, Rongfeng</au><au>Ye, Minjie</au><au>Xu, Xiping</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An updated meta-analysis: apolipoprotein E genotypes and risk of primary open-angle glaucoma</atitle><jtitle>Molecular vision</jtitle><addtitle>Mol Vis</addtitle><date>2014-07-19</date><risdate>2014</risdate><volume>20</volume><spage>1025</spage><epage>1036</epage><pages>1025-1036</pages><eissn>1090-0535</eissn><abstract>To study the association of apolipoprotein E (APOE) polymorphisms and primary open-angle glaucoma (POAG).
After a systematic literature search, all relevant studies evaluating the association between APOE polymorphisms and POAG were included. All statistical tests were calculated with Stata 11.0.
Twelve independent studies on the APOE gene (1,971 cases, 1,756 controls) and POAG were included. A significant association between the APOE gene and POAG was found in the genetic model of ε4/ε4 versus ε3/ε3 (odds ratio [OR] = 2.09, 95% confidence interval [CI] = 1.12-3.88, p = 0.02). However, no association was detected in the models of ε2/ε2 versus ε3/ε3, ε2/ε3 versus ε3/ε3, ε2/ε4 versus ε3/ε3, ε3/ε4 versus ε3/ε3, allele ε2 versus allele ε3, and allele ε4 versus allele ε3. Subgroup analyses showed that a statistically significant association between the APOE gene and the risk of POAG existed in the genetic model of ε4/ε4 versus ε3/ε3 in Asians (OR = 3.55, 95% CI = 1.06-11.87, p = 0.04). No association was identified between the APOE gene and the risk of POAG in Caucasians.
The present meta-analysis indicated that the ε4/ε4 genotype is associated with increased risk of POAG in Asians.</abstract><cop>United States</cop><pub>Molecular Vision</pub><pmid>25053873</pmid><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Apolipoproteins E - genetics Genetic Predisposition to Disease Glaucoma, Open-Angle - ethnology Glaucoma, Open-Angle - genetics Humans Models, Genetic Polymorphism, Genetic Publication Bias Risk Factors |
| title | An updated meta-analysis: apolipoprotein E genotypes and risk of primary open-angle glaucoma |
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