Efficient transduction of myeloid cells by a lentiviral vector that packages the Vpx accessory protein

Lentiviral vectors are widely used for the stable expression of genes and shRNA-mediated knockdown and are currently under development for clinical use in gene therapy. Pseudotyping of the vectors with VSV-G allows them to infect a wide range of cell-types. However, myeloid cells, such as dendritic...

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Veröffentlicht in:Gene therapy 2012-08, Vol.20 (5), p.514-520
Hauptverfasser: Bobadilla, Susanne, Sunseri, Nicole, Landau, Nathaniel R.
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
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