Increased cortical extracellular adenosine correlates with seizure termination

Summary Objective Seizures are currently defined by their electrographic features. However, neuronal networks are intrinsically dependent on neurotransmitters of which little is known regarding their periictal dynamics. Evidence supports adenosine as having a prominent role in seizure termination, a...

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Veröffentlicht in:Epilepsia (Copenhagen) 2014-02, Vol.55 (2), p.233-244
Hauptverfasser: Van Gompel, Jamie J., Bower, Mark R., Worrell, Gregory A., Stead, Matt, Chang, Su‐Youne, Goerss, Stephan J., Kim, Inyong, Bennet, Kevin E., Meyer, Fredric B., Marsh, W. Richard, Blaha, Charles D., Lee, Kendall H.
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container_end_page 244
container_issue 2
container_start_page 233
container_title Epilepsia (Copenhagen)
container_volume 55
creator Van Gompel, Jamie J.
Bower, Mark R.
Worrell, Gregory A.
Stead, Matt
Chang, Su‐Youne
Goerss, Stephan J.
Kim, Inyong
Bennet, Kevin E.
Meyer, Fredric B.
Marsh, W. Richard
Blaha, Charles D.
Lee, Kendall H.
description Summary Objective Seizures are currently defined by their electrographic features. However, neuronal networks are intrinsically dependent on neurotransmitters of which little is known regarding their periictal dynamics. Evidence supports adenosine as having a prominent role in seizure termination, as its administration can terminate and reduce seizures in animal models. Furthermore, microdialysis studies in humans suggest that adenosine is elevated periictally, but the relationship to the seizure is obscured by its temporal measurement limitations. Because electrochemical techniques can provide vastly superior temporal resolution, we test the hypothesis that extracellular adenosine concentrations rise during seizure termination in an animal model and humans using electrochemistry. Methods White farm swine (n = 45) were used in an acute cortical model of epilepsy, and 10 human epilepsy patients were studied during intraoperative electrocorticography (ECoG). Wireless Instantaneous Neurotransmitter Concentration Sensor (WINCS)–based fast scan cyclic voltammetry (FSCV) and fixed potential amperometry were obtained utilizing an adenosine‐specific triangular waveform or biosensors, respectively. Results Simultaneous ECoG and electrochemistry demonstrated an average adenosine increase of 260% compared to baseline, at 7.5 ± 16.9 s with amperometry (n = 75 events) and 2.6 ± 11.2 s with FSCV (n = 15 events) prior to electrographic seizure termination. In agreement with these animal data, adenosine elevation prior to seizure termination in a human patient utilizing FSCV was also seen. Significance Simultaneous ECoG and electrochemical recording supports the hypothesis that adenosine rises prior to seizure termination, suggesting that adenosine itself may be responsible for seizure termination. Future work using intraoperative WINCS–based FSCV recording may help to elucidate the precise relationship between adenosine and seizure termination.
doi_str_mv 10.1111/epi.12511
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Because electrochemical techniques can provide vastly superior temporal resolution, we test the hypothesis that extracellular adenosine concentrations rise during seizure termination in an animal model and humans using electrochemistry. Methods White farm swine (n = 45) were used in an acute cortical model of epilepsy, and 10 human epilepsy patients were studied during intraoperative electrocorticography (ECoG). Wireless Instantaneous Neurotransmitter Concentration Sensor (WINCS)–based fast scan cyclic voltammetry (FSCV) and fixed potential amperometry were obtained utilizing an adenosine‐specific triangular waveform or biosensors, respectively. Results Simultaneous ECoG and electrochemistry demonstrated an average adenosine increase of 260% compared to baseline, at 7.5 ± 16.9 s with amperometry (n = 75 events) and 2.6 ± 11.2 s with FSCV (n = 15 events) prior to electrographic seizure termination. In agreement with these animal data, adenosine elevation prior to seizure termination in a human patient utilizing FSCV was also seen. Significance Simultaneous ECoG and electrochemical recording supports the hypothesis that adenosine rises prior to seizure termination, suggesting that adenosine itself may be responsible for seizure termination. 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Richard</creatorcontrib><creatorcontrib>Blaha, Charles D.</creatorcontrib><creatorcontrib>Lee, Kendall H.</creatorcontrib><title>Increased cortical extracellular adenosine correlates with seizure termination</title><title>Epilepsia (Copenhagen)</title><addtitle>Epilepsia</addtitle><description>Summary Objective Seizures are currently defined by their electrographic features. However, neuronal networks are intrinsically dependent on neurotransmitters of which little is known regarding their periictal dynamics. Evidence supports adenosine as having a prominent role in seizure termination, as its administration can terminate and reduce seizures in animal models. Furthermore, microdialysis studies in humans suggest that adenosine is elevated periictally, but the relationship to the seizure is obscured by its temporal measurement limitations. Because electrochemical techniques can provide vastly superior temporal resolution, we test the hypothesis that extracellular adenosine concentrations rise during seizure termination in an animal model and humans using electrochemistry. Methods White farm swine (n = 45) were used in an acute cortical model of epilepsy, and 10 human epilepsy patients were studied during intraoperative electrocorticography (ECoG). Wireless Instantaneous Neurotransmitter Concentration Sensor (WINCS)–based fast scan cyclic voltammetry (FSCV) and fixed potential amperometry were obtained utilizing an adenosine‐specific triangular waveform or biosensors, respectively. Results Simultaneous ECoG and electrochemistry demonstrated an average adenosine increase of 260% compared to baseline, at 7.5 ± 16.9 s with amperometry (n = 75 events) and 2.6 ± 11.2 s with FSCV (n = 15 events) prior to electrographic seizure termination. In agreement with these animal data, adenosine elevation prior to seizure termination in a human patient utilizing FSCV was also seen. Significance Simultaneous ECoG and electrochemical recording supports the hypothesis that adenosine rises prior to seizure termination, suggesting that adenosine itself may be responsible for seizure termination. Future work using intraoperative WINCS–based FSCV recording may help to elucidate the precise relationship between adenosine and seizure termination.</description><subject>Adenosine</subject><subject>Adenosine - biosynthesis</subject><subject>Adult</subject><subject>Amperometry</subject><subject>Animals</subject><subject>Cerebral Cortex - metabolism</subject><subject>Cerebral Cortex - physiology</subject><subject>Electrochemistry</subject><subject>Electroencephalography - methods</subject><subject>Epilepsy</subject><subject>Extracellular Fluid - metabolism</subject><subject>Extracellular Fluid - physiology</subject><subject>Fast scan cyclic voltammetry</subject><subject>Female</subject><subject>Human trial</subject><subject>Humans</subject><subject>Large animal model</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Purine</subject><subject>Seizure</subject><subject>Seizures - diagnosis</subject><subject>Seizures - metabolism</subject><subject>Seizures - physiopathology</subject><subject>Swine</subject><subject>Young Adult</subject><issn>0013-9580</issn><issn>1528-1167</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUFr2zAYhsVYWbJ0h_2BYtilO7jVZ8mxdRmU0K2B0u2wnoUifW4UHCmV7LbZr688Z2UdTAh00MOj99NLyEegZ5DWOe7sGRQlwBsyhbKoc4B59ZZMKQWWi7KmE_I-xg2ltJpX7B2ZFJzXrGB0Sm6WTgdUEU2mfeisVm2GT11QGtu2b1XIlEHno3U4AAFb1WHMHm23ziLaX33ArMOwtU511rtjctSoNuKHwzkjt18vfy6u8uvv35aLi-tcc84gN7pGDUwwVuB83iAqDnRVGiOQ67ISgvKiaRCE4LwEVWmjamq0NqLkCAbYjHwZvbt-tUWj0aXIrdwFu1VhL72y8vWNs2t55x9keodzMQhOD4Lg73uMndzaOMysHPo-SuBCAK9Y2jPy6R904_vg0ngDVRXps4syUZ9HSgcfY8DmJQxQObQkU0vyd0uJPfk7_Qv5p5YEnI_Ao21x_3-TvPyxHJXPYJadyQ</recordid><startdate>201402</startdate><enddate>201402</enddate><creator>Van Gompel, Jamie J.</creator><creator>Bower, Mark R.</creator><creator>Worrell, Gregory A.</creator><creator>Stead, Matt</creator><creator>Chang, Su‐Youne</creator><creator>Goerss, Stephan J.</creator><creator>Kim, Inyong</creator><creator>Bennet, Kevin E.</creator><creator>Meyer, Fredric B.</creator><creator>Marsh, W. 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Richard</au><au>Blaha, Charles D.</au><au>Lee, Kendall H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased cortical extracellular adenosine correlates with seizure termination</atitle><jtitle>Epilepsia (Copenhagen)</jtitle><addtitle>Epilepsia</addtitle><date>2014-02</date><risdate>2014</risdate><volume>55</volume><issue>2</issue><spage>233</spage><epage>244</epage><pages>233-244</pages><issn>0013-9580</issn><eissn>1528-1167</eissn><coden>EPILAK</coden><abstract>Summary Objective Seizures are currently defined by their electrographic features. However, neuronal networks are intrinsically dependent on neurotransmitters of which little is known regarding their periictal dynamics. Evidence supports adenosine as having a prominent role in seizure termination, as its administration can terminate and reduce seizures in animal models. 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subjects Adenosine
Adenosine - biosynthesis
Adult
Amperometry
Animals
Cerebral Cortex - metabolism
Cerebral Cortex - physiology
Electrochemistry
Electroencephalography - methods
Epilepsy
Extracellular Fluid - metabolism
Extracellular Fluid - physiology
Fast scan cyclic voltammetry
Female
Human trial
Humans
Large animal model
Male
Middle Aged
Purine
Seizure
Seizures - diagnosis
Seizures - metabolism
Seizures - physiopathology
Swine
Young Adult
title Increased cortical extracellular adenosine correlates with seizure termination
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