An improved axillary staging system using the OSNA assay does not modify the therapeutic management of breast cancer patients
The one-step nucleic acid amplification (OSNA) assay is a molecular procedure that can identify deposits of breast cancer (BC) cells in the sentinel lymph node (SLN). We examined the consistency of the OSNA assay with a classic hematoxylin-eosin (H&E)-based immunohistochemistry (IHC) study and e...
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| Veröffentlicht in: | Scientific reports 2014-07, Vol.4 (1), p.5743-5743, Article 5743 |
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| creator | Ruano, Miguel Alonso Lopez-Bonet, Eugeni Buxó, Maria Tuca-Rodríguez, Francesc Vila-Camps, Ester Alvarez, Elena Martin-Castillo, Begoña Menendez, Javier A. |
| description | The one-step nucleic acid amplification (OSNA) assay is a molecular procedure that can identify deposits of breast cancer (BC) cells in the sentinel lymph node (SLN). We examined the consistency of the OSNA assay with a classic hematoxylin-eosin (H&E)-based immunohistochemistry (IHC) study and evaluated how OSNA-based axillary staging might impact the therapeutic management of BC patients. SLN biopsy results were considered to be positive in 60 patients (40%) in the OSNA group (N = 148) and in 43 (28%) patients in the IHC cohort (N = 153, p = 0.023). There was no difference in the macrometastasis (22% for OSNA, 15% for H&E, p = 0.139) or micrometastasis (19% for OSNA, 13% for H&E, p = 0.166) rates, but we found statistically significant differences in the number of isolated tumor cells (1% for OSNA, 11% for H&E, p < 0.001). There were no differences in the administration rate of adjuvant systemic therapy between the OSNA (66% in the SLN
+
patients) and the H&E (74% in the SLN
+
patients) groups (p = 0.159). The OSNA assay allows for the detection of SLN metastases more precisely than conventional pathologic methods but does not alter the therapeutic management of SLN
+
BC patients. |
| doi_str_mv | 10.1038/srep05743 |
| format | Article |
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+
patients) and the H&E (74% in the SLN
+
patients) groups (p = 0.159). The OSNA assay allows for the detection of SLN metastases more precisely than conventional pathologic methods but does not alter the therapeutic management of SLN
+
BC patients.]]></description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep05743</identifier><identifier>PMID: 25034150</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>13 ; 13/56 ; 38 ; 38/77 ; 692/420/755 ; 692/499 ; 692/699/67/1347 ; 692/700/565/1436/99 ; Adult ; Aged ; Axilla ; Biopsy ; Breast cancer ; Breast Neoplasms - drug therapy ; Breast Neoplasms - genetics ; Breast Neoplasms - pathology ; Carcinoma, Ductal, Breast - drug therapy ; Carcinoma, Ductal, Breast - genetics ; Carcinoma, Ductal, Breast - secondary ; Chemotherapy, Adjuvant ; Female ; Humanities and Social Sciences ; Humans ; Immunohistochemistry ; Lymph ; Lymph nodes ; Lymph Nodes - pathology ; Lymphatic Metastasis ; Metastases ; Middle Aged ; Molecular Diagnostic Techniques ; multidisciplinary ; Neoplasm Staging - methods ; Nucleic Acid Amplification Techniques ; Nucleic acids ; Quality Improvement ; Science ; Science (multidisciplinary) ; Statistical analysis ; Tumor cells</subject><ispartof>Scientific reports, 2014-07, Vol.4 (1), p.5743-5743, Article 5743</ispartof><rights>The Author(s) 2014</rights><rights>Copyright Nature Publishing Group Jul 2014</rights><rights>Copyright © 2014, Macmillan Publishers Limited. All rights reserved 2014 Macmillan Publishers Limited. All rights reserved</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-ba63d9256ccca85e6cdfb34cb1afa08c38831d97ba3b69e42d86fe145e641d1a3</citedby><cites>FETCH-LOGICAL-c438t-ba63d9256ccca85e6cdfb34cb1afa08c38831d97ba3b69e42d86fe145e641d1a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102897/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102897/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,27905,27906,41101,42170,51557,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25034150$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ruano, Miguel Alonso</creatorcontrib><creatorcontrib>Lopez-Bonet, Eugeni</creatorcontrib><creatorcontrib>Buxó, Maria</creatorcontrib><creatorcontrib>Tuca-Rodríguez, Francesc</creatorcontrib><creatorcontrib>Vila-Camps, Ester</creatorcontrib><creatorcontrib>Alvarez, Elena</creatorcontrib><creatorcontrib>Martin-Castillo, Begoña</creatorcontrib><creatorcontrib>Menendez, Javier A.</creatorcontrib><title>An improved axillary staging system using the OSNA assay does not modify the therapeutic management of breast cancer patients</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description><![CDATA[The one-step nucleic acid amplification (OSNA) assay is a molecular procedure that can identify deposits of breast cancer (BC) cells in the sentinel lymph node (SLN). We examined the consistency of the OSNA assay with a classic hematoxylin-eosin (H&E)-based immunohistochemistry (IHC) study and evaluated how OSNA-based axillary staging might impact the therapeutic management of BC patients. SLN biopsy results were considered to be positive in 60 patients (40%) in the OSNA group (N = 148) and in 43 (28%) patients in the IHC cohort (N = 153, p = 0.023). There was no difference in the macrometastasis (22% for OSNA, 15% for H&E, p = 0.139) or micrometastasis (19% for OSNA, 13% for H&E, p = 0.166) rates, but we found statistically significant differences in the number of isolated tumor cells (1% for OSNA, 11% for H&E, p < 0.001). There were no differences in the administration rate of adjuvant systemic therapy between the OSNA (66% in the SLN
+
patients) and the H&E (74% in the SLN
+
patients) groups (p = 0.159). The OSNA assay allows for the detection of SLN metastases more precisely than conventional pathologic methods but does not alter the therapeutic management of SLN
+
BC patients.]]></description><subject>13</subject><subject>13/56</subject><subject>38</subject><subject>38/77</subject><subject>692/420/755</subject><subject>692/499</subject><subject>692/699/67/1347</subject><subject>692/700/565/1436/99</subject><subject>Adult</subject><subject>Aged</subject><subject>Axilla</subject><subject>Biopsy</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - drug therapy</subject><subject>Breast Neoplasms - genetics</subject><subject>Breast Neoplasms - pathology</subject><subject>Carcinoma, Ductal, Breast - drug therapy</subject><subject>Carcinoma, Ductal, Breast - genetics</subject><subject>Carcinoma, Ductal, Breast - secondary</subject><subject>Chemotherapy, Adjuvant</subject><subject>Female</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Lymph</subject><subject>Lymph nodes</subject><subject>Lymph Nodes - pathology</subject><subject>Lymphatic Metastasis</subject><subject>Metastases</subject><subject>Middle Aged</subject><subject>Molecular Diagnostic Techniques</subject><subject>multidisciplinary</subject><subject>Neoplasm Staging - 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drug therapy</topic><topic>Breast Neoplasms - genetics</topic><topic>Breast Neoplasms - pathology</topic><topic>Carcinoma, Ductal, Breast - drug therapy</topic><topic>Carcinoma, Ductal, Breast - genetics</topic><topic>Carcinoma, Ductal, Breast - secondary</topic><topic>Chemotherapy, Adjuvant</topic><topic>Female</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Lymph</topic><topic>Lymph nodes</topic><topic>Lymph Nodes - pathology</topic><topic>Lymphatic Metastasis</topic><topic>Metastases</topic><topic>Middle Aged</topic><topic>Molecular Diagnostic Techniques</topic><topic>multidisciplinary</topic><topic>Neoplasm Staging - methods</topic><topic>Nucleic Acid Amplification Techniques</topic><topic>Nucleic acids</topic><topic>Quality Improvement</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Statistical analysis</topic><topic>Tumor cells</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ruano, Miguel Alonso</creatorcontrib><creatorcontrib>Lopez-Bonet, Eugeni</creatorcontrib><creatorcontrib>Buxó, Maria</creatorcontrib><creatorcontrib>Tuca-Rodríguez, Francesc</creatorcontrib><creatorcontrib>Vila-Camps, Ester</creatorcontrib><creatorcontrib>Alvarez, Elena</creatorcontrib><creatorcontrib>Martin-Castillo, Begoña</creatorcontrib><creatorcontrib>Menendez, Javier A.</creatorcontrib><collection>Springer Nature OA/Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ruano, Miguel Alonso</au><au>Lopez-Bonet, Eugeni</au><au>Buxó, Maria</au><au>Tuca-Rodríguez, Francesc</au><au>Vila-Camps, Ester</au><au>Alvarez, Elena</au><au>Martin-Castillo, Begoña</au><au>Menendez, Javier A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An improved axillary staging system using the OSNA assay does not modify the therapeutic management of breast cancer patients</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2014-07-18</date><risdate>2014</risdate><volume>4</volume><issue>1</issue><spage>5743</spage><epage>5743</epage><pages>5743-5743</pages><artnum>5743</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract><![CDATA[The one-step nucleic acid amplification (OSNA) assay is a molecular procedure that can identify deposits of breast cancer (BC) cells in the sentinel lymph node (SLN). We examined the consistency of the OSNA assay with a classic hematoxylin-eosin (H&E)-based immunohistochemistry (IHC) study and evaluated how OSNA-based axillary staging might impact the therapeutic management of BC patients. SLN biopsy results were considered to be positive in 60 patients (40%) in the OSNA group (N = 148) and in 43 (28%) patients in the IHC cohort (N = 153, p = 0.023). There was no difference in the macrometastasis (22% for OSNA, 15% for H&E, p = 0.139) or micrometastasis (19% for OSNA, 13% for H&E, p = 0.166) rates, but we found statistically significant differences in the number of isolated tumor cells (1% for OSNA, 11% for H&E, p < 0.001). There were no differences in the administration rate of adjuvant systemic therapy between the OSNA (66% in the SLN
+
patients) and the H&E (74% in the SLN
+
patients) groups (p = 0.159). The OSNA assay allows for the detection of SLN metastases more precisely than conventional pathologic methods but does not alter the therapeutic management of SLN
+
BC patients.]]></abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>25034150</pmid><doi>10.1038/srep05743</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 13 13/56 38 38/77 692/420/755 692/499 692/699/67/1347 692/700/565/1436/99 Adult Aged Axilla Biopsy Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - pathology Carcinoma, Ductal, Breast - drug therapy Carcinoma, Ductal, Breast - genetics Carcinoma, Ductal, Breast - secondary Chemotherapy, Adjuvant Female Humanities and Social Sciences Humans Immunohistochemistry Lymph Lymph nodes Lymph Nodes - pathology Lymphatic Metastasis Metastases Middle Aged Molecular Diagnostic Techniques multidisciplinary Neoplasm Staging - methods Nucleic Acid Amplification Techniques Nucleic acids Quality Improvement Science Science (multidisciplinary) Statistical analysis Tumor cells |
| title | An improved axillary staging system using the OSNA assay does not modify the therapeutic management of breast cancer patients |
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