Oxidative tissue injury in multiple sclerosis is only partly reflected in experimental disease models

Recent data suggest that oxidative injury may play an important role in demyelination and neurodegeneration in multiple sclerosis (MS). We compared the extent of oxidative injury in MS lesions with that in experimental models driven by different inflammatory mechanisms. It was only in a model of cor...

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Veröffentlicht in:	Acta neuropathologica 2014-08, Vol.128 (2), p.247-266
Hauptverfasser:	Schuh, Cornelia, Wimmer, Isabella, Hametner, Simon, Haider, Lukas, Van Dam, Anne-Marie, Liblau, Roland S., Smith, Ken J., Probert, Lesley, Binder, Christoph J., Bauer, Jan, Bradl, Monika, Mahad, Don, Lassmann, Hans
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - pathology Aging - physiology Animals Autopsies Blood lipids Brain Brain research CD4 Antigens - metabolism CD8 Antigens - metabolism Comparative analysis Coronavirus Infections - immunology Coronavirus Infections - pathology Coronaviruses Cuprizone Disease Disease Models, Animal Encephalomyelitis Encephalomyelitis, Autoimmune, Experimental - immunology Encephalomyelitis, Autoimmune, Experimental - pathology Gene Expression Iron - metabolism Lipopolysaccharides - immunology Lymphocytes Macrophages - pathology Macrophages - physiology Medicine Medicine & Public Health Membrane lipids Mice, Inbred C57BL Microglia - pathology Microglia - physiology Multiple sclerosis Multiple Sclerosis - immunology Multiple Sclerosis - pathology Myelin-Oligodendrocyte Glycoprotein - immunology Nervous system Neurodegeneration Neurosciences Nitric oxide Original Paper Oxidases Oxidative Stress - physiology Pathogenesis Pathology Peptide Fragments - immunology Rats Rats, Inbred Lew Respiratory Burst - physiology T cells T-Lymphocytes - physiology T-Lymphocytes - transplantation
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