RAGE mediates S100A4-induced cell motility via MAPK/ERK and hypoxia signaling and is a prognostic biomarker for human colorectal cancer metastasis

Survival of colorectal cancer patients is strongly dependent on development of distant metastases. S100A4 is a prognostic biomarker and inducer for colorectal cancer metastasis. Besides exerting intracellular functions, S100A4 is secreted extracellularly. The receptor for advanced glycation end prod...

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Veröffentlicht in:	Oncotarget 2014-05, Vol.5 (10), p.3220-3233
Hauptverfasser:	Dahlmann, Mathias, Okhrimenko, Anna, Marcinkowski, Patrick, Osterland, Marc, Herrmann, Pia, Smith, Janice, Heizmann, Claus W, Schlag, Peter M, Stein, Ulrike
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - metabolism Adenocarcinoma - pathology Biomarkers, Tumor - analysis Blotting, Western Cell Hypoxia - physiology Cell Line, Tumor Cell Movement Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Enzyme-Linked Immunosorbent Assay Humans Immunohistochemistry MAP Kinase Signaling System - physiology Neoplasm Invasiveness - pathology Prognosis Real-Time Polymerase Chain Reaction Receptor for Advanced Glycation End Products - metabolism Research Paper S100 Calcium-Binding Protein A4 S100 Proteins - metabolism Signal Transduction - physiology Transfection
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