HGF/MET-directed therapeutics in gastroesophageal cancer: a review of clinical and biomarker development

Aberrant activation of the HGF/MET signaling axis has been strongly implicated in the malignant transformation and progression of gastroesophageal cancer (GEC). MET receptor overexpression in tumor samples from GEC patients has been consistently correlated with an aggressive metastatic phenotype and...

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Veröffentlicht in:	Oncotarget 2014-05, Vol.5 (10), p.2866-2880
Hauptverfasser:	Hack, Stephen P, Bruey, Jean-Marie, Koeppen, Hartmut
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - drug therapy Adenocarcinoma - genetics Adenocarcinoma - metabolism Animals Antineoplastic Agents - pharmacology Biomarkers, Tumor - analysis Drug Design Esophageal Neoplasms - drug therapy Esophageal Neoplasms - genetics Esophageal Neoplasms - metabolism Hepatocyte Growth Factor - genetics Hepatocyte Growth Factor - metabolism Humans Molecular Targeted Therapy - methods Proto-Oncogene Proteins c-met - genetics Proto-Oncogene Proteins c-met - metabolism Review Signal Transduction - drug effects Signal Transduction - physiology Stomach Neoplasms - drug therapy Stomach Neoplasms - genetics Stomach Neoplasms - metabolism
Online-Zugang:	Volltext
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