Hepatic glucose uptake and disposition during short-term high-fat vs. high-fructose feeding

In dogs consuming a high-fat and -fructose diet (52 and 17% of total energy, respectively) for 4 wk, hepatic glucose uptake (HGU) in response to hyperinsulinemia, hyperglycemia, and portal glucose delivery is markedly blunted with reduction in glucokinase (GK) protein and glycogen synthase (GS) acti...

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Veröffentlicht in:	American journal of physiology: endocrinology and metabolism 2014-07, Vol.307 (2), p.E151-E160
Hauptverfasser:	Coate, Katie C, Kraft, Guillaume, Moore, Mary Courtney, Smith, Marta S, Ramnanan, Christopher, Irimia, Jose M, Roach, Peter J, Farmer, Ben, Neal, Doss W, Williams, Phil, Cherrington, Alan D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Glucose - metabolism Diet Diet, High-Fat - veterinary Dietary Carbohydrates - pharmacology Dietary Fats - pharmacology Dogs Fructose - pharmacology Glucokinase - metabolism Glucose Glucose - metabolism Glycerol - metabolism Lactic Acid - metabolism Liver Liver - drug effects Liver - metabolism Male Oils & fats Phosphorylation Triglycerides - metabolism
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