Correlates of Hypertension in Patients with AIDS in the Era of Highly Active Antiretroviral Therapy
Background: It is unclear whether HIV-related factors modify risk of hypertension (HTN). In a cohort of patients with AIDS, the authors determined HTN incidence and prevalence and assessed associated traditional, HIV-specific, and retinal vasculature factors. Methods: Prospective observational cohor...
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| Veröffentlicht in: | Journal of the International Association of Providers of AIDS Care 2013-09, Vol.12 (5), p.325-333 |
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| container_title | Journal of the International Association of Providers of AIDS Care |
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| creator | Krauskopf, Katherine Natta, Mark L. Van Danis, Ronald P. Gangaputra, Sapna Ackatz, Lori Addessi, Adrienne Federman, Alex D. Branch, Andrea D. Meinert, Curtis L. Jabs, Douglas A. |
| description | Background:
It is unclear whether HIV-related factors modify risk of hypertension (HTN). In a cohort of patients with AIDS, the authors determined HTN incidence and prevalence and assessed associated traditional, HIV-specific, and retinal vasculature factors.
Methods:
Prospective observational cohort included 2390 patients with AIDS (1998-2011). Univariate analysis was used to assess the impact of traditional- and AIDS-related risk factors for HTN prevalence and incidence. Multivariate regression analyses were used to evaluate the adjusted impact of these factors.
Results:
Hypertension prevalence was 22% (95% confidence interval [CI] 21%-24%) and was associated with traditional HTN risk factors (age, black race, and higher weight) as well as diabetes, hyperlipidemia, time since AIDS diagnosis, and higher CD4 counts. Hypertension incidence was 64.1 per 1000 person-years (95% CI 58.7/1000-69.9/1000). Age, race, weight, and diabetes were associated with incident HTN but HIV-specific factors were not.
Conclusions:
Hypertension, a prevalent cardiovascular risk factor in patients with AIDS, is associated with traditional and metabolic risk factors. |
| doi_str_mv | 10.1177/2325957413491432 |
| format | Article |
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It is unclear whether HIV-related factors modify risk of hypertension (HTN). In a cohort of patients with AIDS, the authors determined HTN incidence and prevalence and assessed associated traditional, HIV-specific, and retinal vasculature factors.
Methods:
Prospective observational cohort included 2390 patients with AIDS (1998-2011). Univariate analysis was used to assess the impact of traditional- and AIDS-related risk factors for HTN prevalence and incidence. Multivariate regression analyses were used to evaluate the adjusted impact of these factors.
Results:
Hypertension prevalence was 22% (95% confidence interval [CI] 21%-24%) and was associated with traditional HTN risk factors (age, black race, and higher weight) as well as diabetes, hyperlipidemia, time since AIDS diagnosis, and higher CD4 counts. Hypertension incidence was 64.1 per 1000 person-years (95% CI 58.7/1000-69.9/1000). Age, race, weight, and diabetes were associated with incident HTN but HIV-specific factors were not.
Conclusions:
Hypertension, a prevalent cardiovascular risk factor in patients with AIDS, is associated with traditional and metabolic risk factors.</description><identifier>ISSN: 2325-9574</identifier><identifier>ISSN: 2325-9582</identifier><identifier>EISSN: 2325-9582</identifier><identifier>DOI: 10.1177/2325957413491432</identifier><identifier>PMID: 23764503</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Acquired immune deficiency syndrome ; Acquired Immunodeficiency Syndrome - drug therapy ; Acquired Immunodeficiency Syndrome - epidemiology ; Acquired Immunodeficiency Syndrome - physiopathology ; Adolescent ; Adult ; AIDS ; Antiretroviral drugs ; Antiretroviral therapy ; Antiretroviral Therapy, Highly Active - statistics & numerical data ; Blood pressure ; Diabetes ; Female ; HIV ; Human immunodeficiency virus ; Humans ; Hypertension ; Hypertension - epidemiology ; Hypertension - virology ; Incidence ; Male ; Middle Aged ; Odds Ratio ; Patients ; Prescription drugs ; Prevalence ; Prospective Studies ; Risk Factors ; United States - epidemiology</subject><ispartof>Journal of the International Association of Providers of AIDS Care, 2013-09, Vol.12 (5), p.325-333</ispartof><rights>The Author(s) 2013</rights><rights>The Author(s) 2013. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the associated terms available at: https://uk.sagepub.com/en-gb/eur/reusing-open-access-and-sage-choice-content</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3772-e0a9e627f89cb2250dc95dc70c529dfa6bca1d065a77141af1f212d8335cb6b73</citedby><cites>FETCH-LOGICAL-c3772-e0a9e627f89cb2250dc95dc70c529dfa6bca1d065a77141af1f212d8335cb6b73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/2325957413491432$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/2325957413491432$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>230,314,776,780,860,881,21945,27321,27830,27901,27902,33751,44921,45309</link.rule.ids><linktorsrc>$$Uhttps://journals.sagepub.com/doi/full/10.1177/2325957413491432?utm_source=summon&utm_medium=discovery-provider$$EView_record_in_SAGE_Publications$$FView_record_in_$$GSAGE_Publications</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23764503$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Krauskopf, Katherine</creatorcontrib><creatorcontrib>Natta, Mark L. Van</creatorcontrib><creatorcontrib>Danis, Ronald P.</creatorcontrib><creatorcontrib>Gangaputra, Sapna</creatorcontrib><creatorcontrib>Ackatz, Lori</creatorcontrib><creatorcontrib>Addessi, Adrienne</creatorcontrib><creatorcontrib>Federman, Alex D.</creatorcontrib><creatorcontrib>Branch, Andrea D.</creatorcontrib><creatorcontrib>Meinert, Curtis L.</creatorcontrib><creatorcontrib>Jabs, Douglas A.</creatorcontrib><creatorcontrib>Studies of the Ocular Complications of AIDS Research Group</creatorcontrib><title>Correlates of Hypertension in Patients with AIDS in the Era of Highly Active Antiretroviral Therapy</title><title>Journal of the International Association of Providers of AIDS Care</title><addtitle>J Int Assoc Provid AIDS Care</addtitle><description>Background:
It is unclear whether HIV-related factors modify risk of hypertension (HTN). In a cohort of patients with AIDS, the authors determined HTN incidence and prevalence and assessed associated traditional, HIV-specific, and retinal vasculature factors.
Methods:
Prospective observational cohort included 2390 patients with AIDS (1998-2011). Univariate analysis was used to assess the impact of traditional- and AIDS-related risk factors for HTN prevalence and incidence. Multivariate regression analyses were used to evaluate the adjusted impact of these factors.
Results:
Hypertension prevalence was 22% (95% confidence interval [CI] 21%-24%) and was associated with traditional HTN risk factors (age, black race, and higher weight) as well as diabetes, hyperlipidemia, time since AIDS diagnosis, and higher CD4 counts. Hypertension incidence was 64.1 per 1000 person-years (95% CI 58.7/1000-69.9/1000). Age, race, weight, and diabetes were associated with incident HTN but HIV-specific factors were not.
Conclusions:
Hypertension, a prevalent cardiovascular risk factor in patients with AIDS, is associated with traditional and metabolic risk factors.</description><subject>Acquired immune deficiency syndrome</subject><subject>Acquired Immunodeficiency Syndrome - drug therapy</subject><subject>Acquired Immunodeficiency Syndrome - epidemiology</subject><subject>Acquired Immunodeficiency Syndrome - physiopathology</subject><subject>Adolescent</subject><subject>Adult</subject><subject>AIDS</subject><subject>Antiretroviral drugs</subject><subject>Antiretroviral therapy</subject><subject>Antiretroviral Therapy, Highly Active - statistics & numerical data</subject><subject>Blood pressure</subject><subject>Diabetes</subject><subject>Female</subject><subject>HIV</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension - epidemiology</subject><subject>Hypertension - virology</subject><subject>Incidence</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Odds Ratio</subject><subject>Patients</subject><subject>Prescription drugs</subject><subject>Prevalence</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><subject>United States - epidemiology</subject><issn>2325-9574</issn><issn>2325-9582</issn><issn>2325-9582</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>BHHNA</sourceid><recordid>eNp1kc9rFDEUx4MottTePUnAi5fR_M7kIixrtYWCgvUcMpk3OymzkzXJrux_b9atqxbMJeHl877v-_gi9JKSt5Rq_Y5xJo3UgnJhqODsCTo_lBojW_b09NbiDF3mfE_qaZkirX6OzhjXSkjCz5FfxpRgcgUyjgO-3m8gFZhziDMOM_7iSoC5ZPwjlBEvbj58PVTLCPgquV8NYTVOe7zwJewAL-YSEpQUdyG5Cd-NkNxm_wI9G9yU4fLhvkDfPl7dLa-b28-fbpaL28ZzrVkDxBlQTA-t8R1jkvTeyN5r4iUz_eBU5x3tiZJOayqoG-jAKOtbzqXvVKf5BXp_1N1suzX0vhqvLuwmhbVLextdsP_-zGG0q7izghIiW1UF3jwIpPh9C7nYdcgepsnNELfZUiENVdRQXtHXj9D7uE1zXc8yLrhQgpq2UuRI-RRzTjCczFBiDyHaxyHWlld_L3Fq-B1ZBZojkN0K_kz9r-BPCDSj6w</recordid><startdate>201309</startdate><enddate>201309</enddate><creator>Krauskopf, Katherine</creator><creator>Natta, Mark L. Van</creator><creator>Danis, Ronald P.</creator><creator>Gangaputra, Sapna</creator><creator>Ackatz, Lori</creator><creator>Addessi, Adrienne</creator><creator>Federman, Alex D.</creator><creator>Branch, Andrea D.</creator><creator>Meinert, Curtis L.</creator><creator>Jabs, Douglas A.</creator><general>SAGE Publications</general><general>SAGE PUBLICATIONS, INC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7U3</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHHNA</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201309</creationdate><title>Correlates of Hypertension in Patients with AIDS in the Era of Highly Active Antiretroviral Therapy</title><author>Krauskopf, Katherine ; Natta, Mark L. 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Van</au><au>Danis, Ronald P.</au><au>Gangaputra, Sapna</au><au>Ackatz, Lori</au><au>Addessi, Adrienne</au><au>Federman, Alex D.</au><au>Branch, Andrea D.</au><au>Meinert, Curtis L.</au><au>Jabs, Douglas A.</au><aucorp>Studies of the Ocular Complications of AIDS Research Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlates of Hypertension in Patients with AIDS in the Era of Highly Active Antiretroviral Therapy</atitle><jtitle>Journal of the International Association of Providers of AIDS Care</jtitle><addtitle>J Int Assoc Provid AIDS Care</addtitle><date>2013-09</date><risdate>2013</risdate><volume>12</volume><issue>5</issue><spage>325</spage><epage>333</epage><pages>325-333</pages><issn>2325-9574</issn><issn>2325-9582</issn><eissn>2325-9582</eissn><abstract>Background:
It is unclear whether HIV-related factors modify risk of hypertension (HTN). In a cohort of patients with AIDS, the authors determined HTN incidence and prevalence and assessed associated traditional, HIV-specific, and retinal vasculature factors.
Methods:
Prospective observational cohort included 2390 patients with AIDS (1998-2011). Univariate analysis was used to assess the impact of traditional- and AIDS-related risk factors for HTN prevalence and incidence. Multivariate regression analyses were used to evaluate the adjusted impact of these factors.
Results:
Hypertension prevalence was 22% (95% confidence interval [CI] 21%-24%) and was associated with traditional HTN risk factors (age, black race, and higher weight) as well as diabetes, hyperlipidemia, time since AIDS diagnosis, and higher CD4 counts. Hypertension incidence was 64.1 per 1000 person-years (95% CI 58.7/1000-69.9/1000). Age, race, weight, and diabetes were associated with incident HTN but HIV-specific factors were not.
Conclusions:
Hypertension, a prevalent cardiovascular risk factor in patients with AIDS, is associated with traditional and metabolic risk factors.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>23764503</pmid><doi>10.1177/2325957413491432</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | Sage Journals GOLD Open Access 2024 |
| subjects | Acquired immune deficiency syndrome Acquired Immunodeficiency Syndrome - drug therapy Acquired Immunodeficiency Syndrome - epidemiology Acquired Immunodeficiency Syndrome - physiopathology Adolescent Adult AIDS Antiretroviral drugs Antiretroviral therapy Antiretroviral Therapy, Highly Active - statistics & numerical data Blood pressure Diabetes Female HIV Human immunodeficiency virus Humans Hypertension Hypertension - epidemiology Hypertension - virology Incidence Male Middle Aged Odds Ratio Patients Prescription drugs Prevalence Prospective Studies Risk Factors United States - epidemiology |
| title | Correlates of Hypertension in Patients with AIDS in the Era of Highly Active Antiretroviral Therapy |
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