Necroptosis Mediates TNF-Induced Toxicity of Hippocampal Neurons

Tumor necrosis factor-α (TNF-α) is a critical proinflammatory cytokine regulating neuroinflammation. Elevated levels of TNF-α have been associated with various neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. However, the signaling events that lead to TNF-α-i...

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Veröffentlicht in:	BioMed research international 2014-01, Vol.2014 (2014), p.1-11
Hauptverfasser:	Zhu, Yongjin, He, Sudan, Liu, Shan, Li, Jun, Ge, Lin, Yu, Xiaoliang, Wang, Xing, Li, Yun, Xu, Lei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Brain damage Brain research Care and treatment Health aspects Hematology Hippocampus - metabolism Hippocampus - pathology Inflammatory bowel disease Kinases Mice Mice, Knockout Necrosis - metabolism Necrosis - pathology Neurons Neurons - metabolism Neurons - pathology Neurosciences Neurotoxicity Neurotoxicity syndromes Phosphorylation Receptor-Interacting Protein Serine-Threonine Kinases - genetics Receptor-Interacting Protein Serine-Threonine Kinases - metabolism Risk factors Rodents Science Signal Transduction Studies Toxicity Tumor necrosis factor Tumor Necrosis Factor-alpha - metabolism
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