Relative biological effectiveness of therapeutic proton beams for HSG cells at Japanese proton therapy facilities
We investigated the relative biological effectiveness (RBE) of therapeutic proton beams at six proton facilities in Japan with respect to cell lethality of HSG cells. The RBE of treatments could be determined from experimental data. For this purpose, we used a cell survival assay to compare the cell...
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| Veröffentlicht in: | Journal of radiation research 2014-07, Vol.55 (4), p.812-815 |
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| creator | Aoki-Nakano, Mizuho Furusawa, Yoshiya Uzawa, Akiko Matsumoto, Yoshitaka Hirayama, Ryoichi Tsuruoka, Chizuru Ogino, Takashi Nishio, Teiji Kagawa, Kazufumi Murakami, Masao Kagiya, Go Kume, Kyo Hatashita, Masanori Fukuda, Shigekazu Yamamoto, Kazutaka Fuji, Hiroshi Murayama, Shigeyuki Hata, Masaharu Sakae, Takeji Matsumoto, Hideki |
| description | We investigated the relative biological effectiveness (RBE) of therapeutic proton beams at six proton facilities in Japan with respect to cell lethality of HSG cells. The RBE of treatments could be determined from experimental data. For this purpose, we used a cell survival assay to compare the cell-killing efficiency of proton beams. Among the five linear accelerator (LINAC) X-ray machines at 4 or 6 MeV that were used as reference beams, there was only a small variation (coefficient of variation CV = 3.1% at D10) in biological effectiveness. The averaged value of D10 for the proton beams at the middle position of the spread-out Bragg peak (SOBP) was 4.98. These values showed good agreement, with a CV of 4.3% among the facilities. Thus, the average RBE10 (RBE at the D10 level) at the middle position of the SOBP beam for six facilities in Japan was 1.05 with a CV of 2.8%. |
| doi_str_mv | 10.1093/jrr/rru003 |
| format | Article |
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The RBE of treatments could be determined from experimental data. For this purpose, we used a cell survival assay to compare the cell-killing efficiency of proton beams. Among the five linear accelerator (LINAC) X-ray machines at 4 or 6 MeV that were used as reference beams, there was only a small variation (coefficient of variation CV = 3.1% at D10) in biological effectiveness. The averaged value of D10 for the proton beams at the middle position of the spread-out Bragg peak (SOBP) was 4.98. These values showed good agreement, with a CV of 4.3% among the facilities. Thus, the average RBE10 (RBE at the D10 level) at the middle position of the SOBP beam for six facilities in Japan was 1.05 with a CV of 2.8%.</description><identifier>ISSN: 0449-3060</identifier><identifier>EISSN: 1349-9157</identifier><identifier>DOI: 10.1093/jrr/rru003</identifier><identifier>PMID: 24699001</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Beams (radiation) ; Cell Line, Tumor ; Cell Survival - radiation effects ; Coefficient of variation ; Health aspects ; Humans ; Japan ; Lethality ; Linear accelerators ; Nuclear energy ; Proton beams ; Proton Therapy ; Relative Biological Effectiveness ; Relative biological effectiveness (RBE) ; Salivary Gland Neoplasms - pathology ; Salivary Gland Neoplasms - radiotherapy ; Survival ; Technology ; Tumor Stem Cell Assay ; X-rays</subject><ispartof>Journal of radiation research, 2014-07, Vol.55 (4), p.812-815</ispartof><rights>The Author 2014. Published by Oxford University Press on behalf of The Japan Radiation Research Society and Japanese Society for Radiation Oncology. 2014</rights><rights>The Author 2014. Published by Oxford University Press on behalf of The Japan Radiation Research Society and Japanese Society for Radiation Oncology.</rights><rights>COPYRIGHT 2014 Oxford University Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c675t-d830029b8621b264cc3110016618653a47248be497aed828b844fb33720c61d73</citedby><cites>FETCH-LOGICAL-c675t-d830029b8621b264cc3110016618653a47248be497aed828b844fb33720c61d73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4099996/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4099996/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,1599,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24699001$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aoki-Nakano, Mizuho</creatorcontrib><creatorcontrib>Furusawa, Yoshiya</creatorcontrib><creatorcontrib>Uzawa, Akiko</creatorcontrib><creatorcontrib>Matsumoto, Yoshitaka</creatorcontrib><creatorcontrib>Hirayama, Ryoichi</creatorcontrib><creatorcontrib>Tsuruoka, Chizuru</creatorcontrib><creatorcontrib>Ogino, Takashi</creatorcontrib><creatorcontrib>Nishio, Teiji</creatorcontrib><creatorcontrib>Kagawa, Kazufumi</creatorcontrib><creatorcontrib>Murakami, Masao</creatorcontrib><creatorcontrib>Kagiya, Go</creatorcontrib><creatorcontrib>Kume, Kyo</creatorcontrib><creatorcontrib>Hatashita, Masanori</creatorcontrib><creatorcontrib>Fukuda, Shigekazu</creatorcontrib><creatorcontrib>Yamamoto, Kazutaka</creatorcontrib><creatorcontrib>Fuji, Hiroshi</creatorcontrib><creatorcontrib>Murayama, Shigeyuki</creatorcontrib><creatorcontrib>Hata, Masaharu</creatorcontrib><creatorcontrib>Sakae, Takeji</creatorcontrib><creatorcontrib>Matsumoto, Hideki</creatorcontrib><title>Relative biological effectiveness of therapeutic proton beams for HSG cells at Japanese proton therapy facilities</title><title>Journal of radiation research</title><addtitle>J Radiat Res</addtitle><description>We investigated the relative biological effectiveness (RBE) of therapeutic proton beams at six proton facilities in Japan with respect to cell lethality of HSG cells. The RBE of treatments could be determined from experimental data. For this purpose, we used a cell survival assay to compare the cell-killing efficiency of proton beams. Among the five linear accelerator (LINAC) X-ray machines at 4 or 6 MeV that were used as reference beams, there was only a small variation (coefficient of variation CV = 3.1% at D10) in biological effectiveness. The averaged value of D10 for the proton beams at the middle position of the spread-out Bragg peak (SOBP) was 4.98. These values showed good agreement, with a CV of 4.3% among the facilities. Thus, the average RBE10 (RBE at the D10 level) at the middle position of the SOBP beam for six facilities in Japan was 1.05 with a CV of 2.8%.</description><subject>Beams (radiation)</subject><subject>Cell Line, Tumor</subject><subject>Cell Survival - radiation effects</subject><subject>Coefficient of variation</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Japan</subject><subject>Lethality</subject><subject>Linear accelerators</subject><subject>Nuclear energy</subject><subject>Proton beams</subject><subject>Proton Therapy</subject><subject>Relative Biological Effectiveness</subject><subject>Relative biological effectiveness (RBE)</subject><subject>Salivary Gland Neoplasms - pathology</subject><subject>Salivary Gland Neoplasms - radiotherapy</subject><subject>Survival</subject><subject>Technology</subject><subject>Tumor Stem Cell Assay</subject><subject>X-rays</subject><issn>0449-3060</issn><issn>1349-9157</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>TOX</sourceid><sourceid>EIF</sourceid><recordid>eNqNkl1rFTEQhoMo9nj0xh8gARFEOG2yyebjplCKtpWCYOt1yGYnpym7m22yW-i_N4dti4WiJhcJk-d9mZkMQu8p2adEs4PrlA5SmglhL9CKMq43mtbyJVoRXu6MCLKH3uR8TUglSU1eo72KC60JoSt08xM6O4VbwE2IXdwGZzsM3oPbBQfIGUePpytIdoR5Cg6PKU5xwA3YPmMfEz69OMEOui5jO-HvdrRFBQ_YorzD3rrQhSlAfoteedtleHd_rtGvb18vj0835z9Ozo6PzjdOyHratIqVfHWjREWbSnDnGKUlZSGoEjWzXFZcNcC1tNCqSjWKc98wJiviBG0lW6PDxXecmx5aB8OUbGfGFHqb7ky0wTx9GcKV2cZbw4kuSxSDz_cGKd7MkCfTh7wrtBQY52yo1KyqBFH8P1BRa6kVl_9Ga14q5rJ87Bp9XNCt7cCEwceSp9vh5qhmopBK0ELtP0OV3UIfXBzAhxJ_IviyCFyKOSfwjz2hxOwGypSBMstAFfjDn118RB8mqACfFiDO49-MfgPoetNK</recordid><startdate>20140701</startdate><enddate>20140701</enddate><creator>Aoki-Nakano, Mizuho</creator><creator>Furusawa, Yoshiya</creator><creator>Uzawa, Akiko</creator><creator>Matsumoto, Yoshitaka</creator><creator>Hirayama, Ryoichi</creator><creator>Tsuruoka, Chizuru</creator><creator>Ogino, Takashi</creator><creator>Nishio, Teiji</creator><creator>Kagawa, Kazufumi</creator><creator>Murakami, Masao</creator><creator>Kagiya, Go</creator><creator>Kume, Kyo</creator><creator>Hatashita, Masanori</creator><creator>Fukuda, Shigekazu</creator><creator>Yamamoto, Kazutaka</creator><creator>Fuji, Hiroshi</creator><creator>Murayama, Shigeyuki</creator><creator>Hata, Masaharu</creator><creator>Sakae, Takeji</creator><creator>Matsumoto, Hideki</creator><general>Oxford University Press</general><scope>TOX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7ST</scope><scope>C1K</scope><scope>SOI</scope><scope>7SU</scope><scope>7U5</scope><scope>8FD</scope><scope>FR3</scope><scope>L7M</scope><scope>5PM</scope></search><sort><creationdate>20140701</creationdate><title>Relative biological effectiveness of therapeutic proton beams for HSG cells at Japanese proton therapy facilities</title><author>Aoki-Nakano, Mizuho ; 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The RBE of treatments could be determined from experimental data. For this purpose, we used a cell survival assay to compare the cell-killing efficiency of proton beams. Among the five linear accelerator (LINAC) X-ray machines at 4 or 6 MeV that were used as reference beams, there was only a small variation (coefficient of variation CV = 3.1% at D10) in biological effectiveness. The averaged value of D10 for the proton beams at the middle position of the spread-out Bragg peak (SOBP) was 4.98. These values showed good agreement, with a CV of 4.3% among the facilities. Thus, the average RBE10 (RBE at the D10 level) at the middle position of the SOBP beam for six facilities in Japan was 1.05 with a CV of 2.8%.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>24699001</pmid><doi>10.1093/jrr/rru003</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Beams (radiation) Cell Line, Tumor Cell Survival - radiation effects Coefficient of variation Health aspects Humans Japan Lethality Linear accelerators Nuclear energy Proton beams Proton Therapy Relative Biological Effectiveness Relative biological effectiveness (RBE) Salivary Gland Neoplasms - pathology Salivary Gland Neoplasms - radiotherapy Survival Technology Tumor Stem Cell Assay X-rays |
| title | Relative biological effectiveness of therapeutic proton beams for HSG cells at Japanese proton therapy facilities |
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