Cooperative interaction of Etv2 and Gata2 regulates the development of endothelial and hematopoietic lineages

Regulatory mechanisms that govern lineage specification of the mesodermal progenitors to become endothelial and hematopoietic cells remain an area of intense interest. Both Ets and Gata factors have been shown to have important roles in the transcriptional regulation in endothelial and hematopoietic...

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Veröffentlicht in:	Developmental biology 2014-05, Vol.389 (2), p.208-218
Hauptverfasser:	Shi, Xiaozhong, Richard, Jai, Zirbes, Katie M., Gong, Wuming, Lin, Gufa, Kyba, Michael, Thomson, Jamie A., Koyano-Nakagawa, Naoko, Garry, Daniel J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Differentiation - genetics Cell Line Cell Lineage - genetics Embryoid Bodies - cytology Embryoid Bodies - metabolism Embryonic Development - genetics Endothelial cell Endothelial Cells - cytology Endothelial Cells - metabolism Etv2 Gata2 GATA2 Transcription Factor - chemistry GATA2 Transcription Factor - metabolism Gene Expression Regulation, Developmental Hematopoietic cell Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - metabolism Mice Protein Binding Protein Interaction Domains and Motifs Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Trans-Activators - genetics Trans-Activators - metabolism Transcription Factors - chemistry Transcription Factors - metabolism Transcriptional Activation - genetics
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