Intestinal Inflammatory Biomarkers and Outcome in Pediatric Clostridium difficile Infections

Objectives To identify specific fecal biomarkers for symptomatic Clostridium difficile infection and predictors of poor outcomes. Study design We enrolled 65 children with positive C difficile testing (cases) and 37 symptomatic controls. We also analyzed stool samples from colonized and non-colonize...

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Veröffentlicht in:	The Journal of pediatrics 2013-12, Vol.163 (6), p.1697-1704.e2
Hauptverfasser:	El Feghaly, Rana E., MD, Stauber, Jennifer L., MS, Tarr, Phillip I., MD, Haslam, David B., MD
Format:	Artikel
Sprache:	eng
Schlagworte:	biomarkers Biomarkers - analysis Case-Control Studies chemokines Child children Clostridium difficile diarrhea Enterocolitis, Pseudomembranous - diagnosis Enterocolitis, Pseudomembranous - immunology enzyme immunoassays feces Feces - chemistry Female gastroenteritis Humans interleukin-8 Interleukin-8 - analysis lactoferrin Lactoferrin - analysis Male messenger RNA p38 Mitogen-Activated Protein Kinases - analysis patients Pediatrics Prospective Studies quantitative polymerase chain reaction regression analysis therapeutics vancomycin
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