Asialo GM1(+) CD8(+) T cells play a critical role in costimulation blockade-resistant allograft rejection

Simultaneous blockade of the CD40 and CD28 costimulatory pathways is an effective treatment strategy to promote allograft acceptance but does not lead to indefinite allograft survival. The immune mechanisms responsible for costimulation-independent rejection are not defined. Here we have studied the...

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Veröffentlicht in:	The Journal of clinical investigation 1999-12, Vol.104 (12), p.1715-1722
Hauptverfasser:	Trambley, J, Bingaman, A W, Lin, A, Elwood, E T, Waitze, S Y, Ha, J, Durham, M M, Corbascio, M, Cowan, S R, Pearson, T C, Larsen, C P
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Animals CD28 Antigens - physiology CD40 Antigens - physiology CD8-Positive T-Lymphocytes - physiology G(M1) Ganglioside - physiology Graft Rejection Killer Cells, Natural - physiology Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Receptors, Antigen, T-Cell, gamma-delta - analysis Skin Transplantation - immunology Transplantation, Homologous
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