A monoclonal antibody that targets a NaV1.7 channel voltage sensor for pain and itch relief

Voltage-gated sodium (NaV) channels control the upstroke of the action potentials in excitable cells. Multiple studies have shown distinct roles of NaV channel subtypes in human physiology and diseases, but subtype-specific therapeutics are lacking and the current efforts have been limited to small...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cell 2014-06, Vol.157 (6), p.1393-1404
Hauptverfasser:	Lee, Jun-Ho, Park, Chul-Kyu, Chen, Gang, Han, Qingjian, Xie, Rou-Gang, Liu, Tong, Ji, Ru-Rong, Lee, Seok-Yong
Format:	Artikel
Sprache:	eng
Schlagworte:	action potentials Amino Acid Sequence Animals Antibodies, Monoclonal - therapeutic use cations HEK293 Cells human physiology Humans Inflammation - chemically induced Inflammation - pathology Mice Models, Molecular Molecular Sequence Data monoclonal antibodies NAV1.7 Voltage-Gated Sodium Channel - chemistry NAV1.7 Voltage-Gated Sodium Channel - metabolism Neurons - metabolism pain Pain - drug therapy Pruritus - drug therapy Sequence Alignment sodium spinal cord Spinal Cord - metabolism synaptic transmission Synaptic Transmission - drug effects therapeutics Voltage-Gated Sodium Channel Blockers - therapeutic use
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!