Identification of amino acid substitutions with compensational effects in the attachment protein of canine distemper virus

The hemagglutinin (H) gene of canine distemper virus (CDV) encodes the receptor-binding protein. This protein, together with the fusion (F) protein, is pivotal for infectivity since it contributes to the fusion of the viral envelope with the host cell membrane. Of the two receptors currently known f...

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Veröffentlicht in:	Journal of virology 2014-07, Vol.88 (14), p.8057-8064
Hauptverfasser:	Sattler, Ursula, Khosravi, Mojtaba, Avila, Mislay, Pilo, Paola, Langedijk, Johannes P, Ader-Ebert, Nadine, Alves, Lisa A, Plattet, Philippe, Origgi, Francesco C
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Animals Animals, Wild Antigens, CD - metabolism Canine distemper virus Distemper - epidemiology Distemper - virology Distemper Virus, Canine - genetics Distemper Virus, Canine - isolation & purification Distemper Virus, Canine - physiology DNA Mutational Analysis Europe - epidemiology Evolution, Molecular Hemagglutinins, Viral - genetics Hemagglutinins, Viral - metabolism Mutagenesis, Site-Directed Mutant Proteins - genetics Mutant Proteins - metabolism Mutation, Missense Protein Binding Receptors, Cell Surface - metabolism Receptors, Virus - metabolism Signaling Lymphocytic Activation Molecule Family Member 1 Structure and Assembly Suppression, Genetic Viral Fusion Proteins - metabolism Virus Attachment
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