Extremes of age are associated with indeterminate QuantiFERON-TB gold assay results

Extremes of age are associated with indeterminate QuantiFERON-TB gold assay results

Results from 3,263 QuantiFERON-TB Gold in-tube (QFT-GIT) assays were analyzed to determine the impact of age on test performance. The proportion of indeterminate results was significantly higher in pediatric and elderly (9.1% and 7.4%, respectively) than in adult (2.6%; chi-square test, P < 0.000...

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Veröffentlicht in:Journal of clinical microbiology 2014-07, Vol.52 (7), p.2694-2697
Hauptverfasser: Tebruegge, Marc, de Graaf, Hans, Sukhtankar, Priya, Elkington, Paul, Marshall, Ben, Schuster, Helmut, Patel, Sanjay, Faust, Saul N
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Child
Child, Preschool
Female
Humans
Infant
Infant, Newborn
Interferon-gamma Release Tests - methods
Male
Middle Aged
Mycobacteriology and Aerobic Actinomycetes
Sensitivity and Specificity
Tuberculosis - diagnosis
Young Adult
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Zusammenfassung:Results from 3,263 QuantiFERON-TB Gold in-tube (QFT-GIT) assays were analyzed to determine the impact of age on test performance. The proportion of indeterminate results was significantly higher in pediatric and elderly (9.1% and 7.4%, respectively) than in adult (2.6%; chi-square test, P < 0.0001) patients. A detailed analysis of indeterminate QFT-GIT assay results is presented.
ISSN:0095-1137
1098-660X
DOI:10.1128/JCM.00814-14