Maternal autism-associated IgG antibodies delay development and produce anxiety in a mouse gestational transfer model
Abstract A murine passive transfer model system was employed to ascertain the effects of gestational exposure to a single, intravenous dose of purified, brain-reactive IgG antibodies from individual mothers of children with autism (MAU) or mothers with typically developing children (MTD). Growth and...
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| Veröffentlicht in: | Journal of neuroimmunology 2012-11, Vol.252 (1), p.56-65 |
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| container_title | Journal of neuroimmunology |
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| creator | Braunschweig, Daniel Golub, Mari S Koenig, Claire M Qi, Lihong Pessah, Isaac N Van de Water, Judy Berman, Robert F |
| description | Abstract A murine passive transfer model system was employed to ascertain the effects of gestational exposure to a single, intravenous dose of purified, brain-reactive IgG antibodies from individual mothers of children with autism (MAU) or mothers with typically developing children (MTD). Growth and behavioral outcomes in offspring were measured from postnatal days 8 to 65 in each group. Comparisons revealed alterations in early growth trajectories, significantly impaired motor and sensory development, and increased anxiety. This report demonstrates for the first time the effects of a single, low dose gestational exposure of IgG derived from individual MAU on their offspring's physical and social development. |
| doi_str_mv | 10.1016/j.jneuroim.2012.08.002 |
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Growth and behavioral outcomes in offspring were measured from postnatal days 8 to 65 in each group. Comparisons revealed alterations in early growth trajectories, significantly impaired motor and sensory development, and increased anxiety. This report demonstrates for the first time the effects of a single, low dose gestational exposure of IgG derived from individual MAU on their offspring's physical and social development.</description><identifier>ISSN: 0165-5728</identifier><identifier>EISSN: 1872-8421</identifier><identifier>DOI: 10.1016/j.jneuroim.2012.08.002</identifier><identifier>PMID: 22951357</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Allergy and Immunology ; Animals ; Anxiety ; Anxiety - immunology ; Autism ; Autistic Disorder - immunology ; Autoantibodies - administration & dosage ; Autoantibodies - immunology ; Autoantigens - immunology ; Behavior, Animal - drug effects ; Brain - immunology ; Children ; Development ; Disease Models, Animal ; Female ; Growth and Development - drug effects ; Humans ; Immune ; Immunoglobulin G ; Immunoglobulin G - administration & dosage ; Immunoglobulin G - immunology ; Intravenous administration ; Maternal antibodies ; Mice ; Mice, Inbred C57BL ; Mothers ; Mouse behavior ; Neurology ; Passive transfer ; Pregnancy ; Prenatal Exposure Delayed Effects - immunology ; Progeny</subject><ispartof>Journal of neuroimmunology, 2012-11, Vol.252 (1), p.56-65</ispartof><rights>2012</rights><rights>Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c625t-e737b74a88d70570565f7abdaf0e8f52c2e02ba07dec02b7f35dab544b62f0fa3</citedby><cites>FETCH-LOGICAL-c625t-e737b74a88d70570565f7abdaf0e8f52c2e02ba07dec02b7f35dab544b62f0fa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jneuroim.2012.08.002$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22951357$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Braunschweig, Daniel</creatorcontrib><creatorcontrib>Golub, Mari S</creatorcontrib><creatorcontrib>Koenig, Claire M</creatorcontrib><creatorcontrib>Qi, Lihong</creatorcontrib><creatorcontrib>Pessah, Isaac N</creatorcontrib><creatorcontrib>Van de Water, Judy</creatorcontrib><creatorcontrib>Berman, Robert F</creatorcontrib><title>Maternal autism-associated IgG antibodies delay development and produce anxiety in a mouse gestational transfer model</title><title>Journal of neuroimmunology</title><addtitle>J Neuroimmunol</addtitle><description>Abstract A murine passive transfer model system was employed to ascertain the effects of gestational exposure to a single, intravenous dose of purified, brain-reactive IgG antibodies from individual mothers of children with autism (MAU) or mothers with typically developing children (MTD). Growth and behavioral outcomes in offspring were measured from postnatal days 8 to 65 in each group. Comparisons revealed alterations in early growth trajectories, significantly impaired motor and sensory development, and increased anxiety. This report demonstrates for the first time the effects of a single, low dose gestational exposure of IgG derived from individual MAU on their offspring's physical and social development.</description><subject>Allergy and Immunology</subject><subject>Animals</subject><subject>Anxiety</subject><subject>Anxiety - immunology</subject><subject>Autism</subject><subject>Autistic Disorder - immunology</subject><subject>Autoantibodies - administration & dosage</subject><subject>Autoantibodies - immunology</subject><subject>Autoantigens - immunology</subject><subject>Behavior, Animal - drug effects</subject><subject>Brain - immunology</subject><subject>Children</subject><subject>Development</subject><subject>Disease Models, Animal</subject><subject>Female</subject><subject>Growth and Development - drug effects</subject><subject>Humans</subject><subject>Immune</subject><subject>Immunoglobulin G</subject><subject>Immunoglobulin G - administration & dosage</subject><subject>Immunoglobulin G - immunology</subject><subject>Intravenous administration</subject><subject>Maternal antibodies</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mothers</subject><subject>Mouse behavior</subject><subject>Neurology</subject><subject>Passive transfer</subject><subject>Pregnancy</subject><subject>Prenatal Exposure Delayed Effects - immunology</subject><subject>Progeny</subject><issn>0165-5728</issn><issn>1872-8421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUk1v1DAQjRCILoW_UOXIJcF24nxcKlBVSqUiDsDZmtiTxUtiL7azYv89E21bAZdKlj3yvHme5zdZdsFZyRlv3u3KncMleDuXgnFRsq5kTDzLNrxrRdHVgj_PNgSUhWxFd5a9inHHGJdV3b_MzoToJa9ku8mWz5AwOJhyWJKNcwExem3p0uS325scXLKDNxZjbnCCI-0HnPx-RpcoafJ98GbRSPFvi-mYW5dDPvslYr7FmCBZv7KnAC6OGChFPK-zFyNMEd_cn-fZ94_X364-FXdfbm6vPtwVuhEyFdhW7dDW0HWmZZJWI8cWBgMjw26UQgtkYgDWGtQUtGMlDQyyrodGjGyE6jy7PPHul2FGo6npAJPaBztDOCoPVv2bcfaH2vqDqlnf9B0jgrf3BMH_WkiPmm3UOE3gkDQqznklBCcLnoayXtay4V1P0OYE1cHHGHB87IgztdqrdurBXrXaq1inyF4qvPhbz2PZg58EeH8CIP3qwWJQUVt0Go0NqJMy3j79xuV_FHqyzmqYfuIR484v67iQHhWpRn1dh2ydMfoEJuqmr_4Acd_Srg</recordid><startdate>20121115</startdate><enddate>20121115</enddate><creator>Braunschweig, Daniel</creator><creator>Golub, Mari S</creator><creator>Koenig, Claire M</creator><creator>Qi, Lihong</creator><creator>Pessah, Isaac N</creator><creator>Van de Water, Judy</creator><creator>Berman, Robert F</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>20121115</creationdate><title>Maternal autism-associated IgG antibodies delay development and produce anxiety in a mouse gestational transfer model</title><author>Braunschweig, Daniel ; Golub, Mari S ; Koenig, Claire M ; Qi, Lihong ; Pessah, Isaac N ; Van de Water, Judy ; Berman, Robert F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c625t-e737b74a88d70570565f7abdaf0e8f52c2e02ba07dec02b7f35dab544b62f0fa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Allergy and Immunology</topic><topic>Animals</topic><topic>Anxiety</topic><topic>Anxiety - immunology</topic><topic>Autism</topic><topic>Autistic Disorder - immunology</topic><topic>Autoantibodies - administration & dosage</topic><topic>Autoantibodies - immunology</topic><topic>Autoantigens - immunology</topic><topic>Behavior, Animal - drug effects</topic><topic>Brain - immunology</topic><topic>Children</topic><topic>Development</topic><topic>Disease Models, Animal</topic><topic>Female</topic><topic>Growth and Development - drug effects</topic><topic>Humans</topic><topic>Immune</topic><topic>Immunoglobulin G</topic><topic>Immunoglobulin G - administration & dosage</topic><topic>Immunoglobulin G - immunology</topic><topic>Intravenous administration</topic><topic>Maternal antibodies</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mothers</topic><topic>Mouse behavior</topic><topic>Neurology</topic><topic>Passive transfer</topic><topic>Pregnancy</topic><topic>Prenatal Exposure Delayed Effects - immunology</topic><topic>Progeny</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Braunschweig, Daniel</creatorcontrib><creatorcontrib>Golub, Mari S</creatorcontrib><creatorcontrib>Koenig, Claire M</creatorcontrib><creatorcontrib>Qi, Lihong</creatorcontrib><creatorcontrib>Pessah, Isaac N</creatorcontrib><creatorcontrib>Van de Water, Judy</creatorcontrib><creatorcontrib>Berman, Robert F</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of neuroimmunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Braunschweig, Daniel</au><au>Golub, Mari S</au><au>Koenig, Claire M</au><au>Qi, Lihong</au><au>Pessah, Isaac N</au><au>Van de Water, Judy</au><au>Berman, Robert F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Maternal autism-associated IgG antibodies delay development and produce anxiety in a mouse gestational transfer model</atitle><jtitle>Journal of neuroimmunology</jtitle><addtitle>J Neuroimmunol</addtitle><date>2012-11-15</date><risdate>2012</risdate><volume>252</volume><issue>1</issue><spage>56</spage><epage>65</epage><pages>56-65</pages><issn>0165-5728</issn><eissn>1872-8421</eissn><abstract>Abstract A murine passive transfer model system was employed to ascertain the effects of gestational exposure to a single, intravenous dose of purified, brain-reactive IgG antibodies from individual mothers of children with autism (MAU) or mothers with typically developing children (MTD). Growth and behavioral outcomes in offspring were measured from postnatal days 8 to 65 in each group. Comparisons revealed alterations in early growth trajectories, significantly impaired motor and sensory development, and increased anxiety. This report demonstrates for the first time the effects of a single, low dose gestational exposure of IgG derived from individual MAU on their offspring's physical and social development.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>22951357</pmid><doi>10.1016/j.jneuroim.2012.08.002</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Allergy and Immunology Animals Anxiety Anxiety - immunology Autism Autistic Disorder - immunology Autoantibodies - administration & dosage Autoantibodies - immunology Autoantigens - immunology Behavior, Animal - drug effects Brain - immunology Children Development Disease Models, Animal Female Growth and Development - drug effects Humans Immune Immunoglobulin G Immunoglobulin G - administration & dosage Immunoglobulin G - immunology Intravenous administration Maternal antibodies Mice Mice, Inbred C57BL Mothers Mouse behavior Neurology Passive transfer Pregnancy Prenatal Exposure Delayed Effects - immunology Progeny |
| title | Maternal autism-associated IgG antibodies delay development and produce anxiety in a mouse gestational transfer model |
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