Design, synthesis and evaluation of estradiol-linked genotoxicants as anticancer agents

A series of bifunctional compounds was prepared consisting of 17β estradiol linked to a DNA damaging N,N-bis (2-chloroethyl)-aniline. The objective of our studies was to detem1ine the characteristics of the linker that permitted both reaction with DNA and binding of the resultant covalent adducts to...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2004-07, Vol.14 (14), p.3829-3833
Hauptverfasser:	Sharma, Uday, Marquis, Jolm C., Dinaut, A. Nicole, Hillier, Shawn M., Fedeles, Bogdan, Rye, Peter T., Essigmann, John M., Croy, Robert G.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!