Angiotensin 1–7 Reduces Mortality and Rupture of Intracranial Aneurysms in Mice
Angiotensin II (Ang II) stimulates vascular inflammation, oxidative stress, and formation and rupture of intracranial aneurysms in mice. Because Ang 1–7 acts on Mas receptors and generally counteracts deleterious effects of Ang II, we tested the hypothesis that Ang 1–7 attenuates formation and ruptu...
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| Veröffentlicht in: | Hypertension (Dallas, Tex. 1979) Tex. 1979), 2014-08, Vol.64 (2), p.362-368 |
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| container_title | Hypertension (Dallas, Tex. 1979) |
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| creator | Peña Silva, Ricardo A Kung, David K Mitchell, Ian J Alenina, Natalia Bader, Michael Santos, Robson A.S Faraci, Frank M Heistad, Donald D Hasan, David M |
| description | Angiotensin II (Ang II) stimulates vascular inflammation, oxidative stress, and formation and rupture of intracranial aneurysms in mice. Because Ang 1–7 acts on Mas receptors and generally counteracts deleterious effects of Ang II, we tested the hypothesis that Ang 1–7 attenuates formation and rupture of intracranial aneurysms. Intracranial aneurysms were induced in wild-type and Mas receptor–deficient mice using a combination of Ang II–induced hypertension and intracranial injection of elastase in the basal cistern. Mice received elastase+Ang II alone or a combination of elastase+Ang II+Ang 1–7. Aneurysm formation, prevalence of subarachnoid hemorrhage, mortality, and expression of molecules involved in vascular injury were assessed. Systolic blood pressure was similar in mice receiving elastase+Ang II (mean±SE, 148±5 mm Hg) or elastase+Ang II+Ang 1–7 (144±5 mm Hg). Aneurysm formation was also similar in mice receiving elastase+Ang II (89%) or elastase+Ang II+Ang 1–7 (84%). However, mice that received elastase+Ang II+Ang 1–7 had reduced mortality (from 64% to 36%; P |
| doi_str_mv | 10.1161/HYPERTENSIONAHA.114.03415 |
| format | Article |
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Because Ang 1–7 acts on Mas receptors and generally counteracts deleterious effects of Ang II, we tested the hypothesis that Ang 1–7 attenuates formation and rupture of intracranial aneurysms. Intracranial aneurysms were induced in wild-type and Mas receptor–deficient mice using a combination of Ang II–induced hypertension and intracranial injection of elastase in the basal cistern. Mice received elastase+Ang II alone or a combination of elastase+Ang II+Ang 1–7. Aneurysm formation, prevalence of subarachnoid hemorrhage, mortality, and expression of molecules involved in vascular injury were assessed. Systolic blood pressure was similar in mice receiving elastase+Ang II (mean±SE, 148±5 mm Hg) or elastase+Ang II+Ang 1–7 (144±5 mm Hg). Aneurysm formation was also similar in mice receiving elastase+Ang II (89%) or elastase+Ang II+Ang 1–7 (84%). However, mice that received elastase+Ang II+Ang 1–7 had reduced mortality (from 64% to 36%; P<0.05) and prevalence of subarachnoid hemorrhage (from 75% to 48%; P<0.05). In cerebral arteries, expression of the inflammatory markers, Nox2 and catalase increased similarly in elastase+Ang II or elastase+Ang II+Ang 1–7 groups. Ang 1–7 increased the expression of cyclooxygenase-2 and decreased the expression of matrix metalloproteinase-9 induced by elastase+Ang II (P<0.05). In Mas receptor–deficient mice, systolic blood pressure, mortality, and prevalence of subarachnoid hemorrhage were similar (P>0.05) in groups treated with elastase+Ang II or elastase+Ang II+Ang 1–7. The expression of Mas receptor was detected by immunohistochemistry in samples of human intracranial arteries and aneurysms. In conclusion, without attenuating Ang II–induced hypertension, Ang 1–7 decreased mortality and rupture of intracranial aneurysms in mice through a Mas receptor–dependent pathway.</description><identifier>ISSN: 0194-911X</identifier><identifier>EISSN: 1524-4563</identifier><identifier>DOI: 10.1161/HYPERTENSIONAHA.114.03415</identifier><identifier>PMID: 24799613</identifier><identifier>CODEN: HPRTDN</identifier><language>eng</language><publisher>Hagerstown, MD: American Heart Association, Inc</publisher><subject>Aneurysm, Ruptured - drug therapy ; Aneurysm, Ruptured - mortality ; Aneurysm, Ruptured - prevention & control ; Angiotensin I - pharmacology ; Angiotensin I - therapeutic use ; Animals ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood Pressure - drug effects ; Cardiology. Vascular system ; Humans ; Intracranial Aneurysm - drug therapy ; Intracranial Aneurysm - mortality ; Medical sciences ; Mice ; Mice, Knockout ; Neurology ; Oxidative Stress - drug effects ; Peptide Fragments - pharmacology ; Peptide Fragments - therapeutic use ; Proto-Oncogene Proteins - genetics ; Proto-Oncogene Proteins - metabolism ; Receptors, G-Protein-Coupled - genetics ; Receptors, G-Protein-Coupled - metabolism ; Vascular diseases and vascular malformations of the nervous system</subject><ispartof>Hypertension (Dallas, Tex. 1979), 2014-08, Vol.64 (2), p.362-368</ispartof><rights>2014 American Heart Association, Inc</rights><rights>2015 INIST-CNRS</rights><rights>2014 American Heart Association, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6435-f6a753ddb86d21a8f6e5795fc57047285dd8b74e0c0c0026eb8fe39f40f3bd353</citedby><cites>FETCH-LOGICAL-c6435-f6a753ddb86d21a8f6e5795fc57047285dd8b74e0c0c0026eb8fe39f40f3bd353</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,3674,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28610653$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24799613$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Peña Silva, Ricardo A</creatorcontrib><creatorcontrib>Kung, David K</creatorcontrib><creatorcontrib>Mitchell, Ian J</creatorcontrib><creatorcontrib>Alenina, Natalia</creatorcontrib><creatorcontrib>Bader, Michael</creatorcontrib><creatorcontrib>Santos, Robson A.S</creatorcontrib><creatorcontrib>Faraci, Frank M</creatorcontrib><creatorcontrib>Heistad, Donald D</creatorcontrib><creatorcontrib>Hasan, David M</creatorcontrib><title>Angiotensin 1–7 Reduces Mortality and Rupture of Intracranial Aneurysms in Mice</title><title>Hypertension (Dallas, Tex. 1979)</title><addtitle>Hypertension</addtitle><description>Angiotensin II (Ang II) stimulates vascular inflammation, oxidative stress, and formation and rupture of intracranial aneurysms in mice. Because Ang 1–7 acts on Mas receptors and generally counteracts deleterious effects of Ang II, we tested the hypothesis that Ang 1–7 attenuates formation and rupture of intracranial aneurysms. Intracranial aneurysms were induced in wild-type and Mas receptor–deficient mice using a combination of Ang II–induced hypertension and intracranial injection of elastase in the basal cistern. Mice received elastase+Ang II alone or a combination of elastase+Ang II+Ang 1–7. Aneurysm formation, prevalence of subarachnoid hemorrhage, mortality, and expression of molecules involved in vascular injury were assessed. Systolic blood pressure was similar in mice receiving elastase+Ang II (mean±SE, 148±5 mm Hg) or elastase+Ang II+Ang 1–7 (144±5 mm Hg). Aneurysm formation was also similar in mice receiving elastase+Ang II (89%) or elastase+Ang II+Ang 1–7 (84%). However, mice that received elastase+Ang II+Ang 1–7 had reduced mortality (from 64% to 36%; P<0.05) and prevalence of subarachnoid hemorrhage (from 75% to 48%; P<0.05). In cerebral arteries, expression of the inflammatory markers, Nox2 and catalase increased similarly in elastase+Ang II or elastase+Ang II+Ang 1–7 groups. Ang 1–7 increased the expression of cyclooxygenase-2 and decreased the expression of matrix metalloproteinase-9 induced by elastase+Ang II (P<0.05). In Mas receptor–deficient mice, systolic blood pressure, mortality, and prevalence of subarachnoid hemorrhage were similar (P>0.05) in groups treated with elastase+Ang II or elastase+Ang II+Ang 1–7. The expression of Mas receptor was detected by immunohistochemistry in samples of human intracranial arteries and aneurysms. In conclusion, without attenuating Ang II–induced hypertension, Ang 1–7 decreased mortality and rupture of intracranial aneurysms in mice through a Mas receptor–dependent pathway.</description><subject>Aneurysm, Ruptured - drug therapy</subject><subject>Aneurysm, Ruptured - mortality</subject><subject>Aneurysm, Ruptured - prevention & control</subject><subject>Angiotensin I - pharmacology</subject><subject>Angiotensin I - therapeutic use</subject><subject>Animals</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Blood Pressure - drug effects</subject><subject>Cardiology. Vascular system</subject><subject>Humans</subject><subject>Intracranial Aneurysm - drug therapy</subject><subject>Intracranial Aneurysm - mortality</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Knockout</subject><subject>Neurology</subject><subject>Oxidative Stress - drug effects</subject><subject>Peptide Fragments - pharmacology</subject><subject>Peptide Fragments - therapeutic use</subject><subject>Proto-Oncogene Proteins - genetics</subject><subject>Proto-Oncogene Proteins - metabolism</subject><subject>Receptors, G-Protein-Coupled - genetics</subject><subject>Receptors, G-Protein-Coupled - metabolism</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><issn>0194-911X</issn><issn>1524-4563</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkctu1DAUhi0EotPCK6CwQOomxY4vSRYgRdXAjNQLDEWCleU4xx2DxxnspNXseAfekCfBwwzlskJeWDrnO__5dX6EnhJ8Qoggz2cf30wXV9OLd_PLi2bWpCI7wZQRfg9NCC9Yzrig99EEk5rlNSEfDtBhjJ8wJoyx8iE6KFhZ14LQCXrb-GvbD-Cj9Rn5_vVbmS2gGzXE7LwPg3J22GTKd9liXA9jgKw32dwPQemgvFUuazyMYRNXMUsC51bDI_TAKBfh8f4_Qu9fTa9OZ_nZ5ev5aXOWa8Eoz41QJadd11aiK4iqjABe1txoXmJWFhXvuqotGWCdHi4EtJUBWhuGDW07yukRernTXY_tCjoNW1dOroNdqbCRvbLy7463S3nd30iGa8GKIgkc7wVC_2WEOMiVjRqcUx76MUrC07Foxcl2V71DdehjDGDu1hAst5HIfyJJRSZ_RpJmn_zp827yVwYJeLYHVNTKmXRYbeNvrhIEC77lXuy4294NEOJnN95CkEtQblj-h5EfR5SsGg</recordid><startdate>201408</startdate><enddate>201408</enddate><creator>Peña Silva, Ricardo A</creator><creator>Kung, David K</creator><creator>Mitchell, Ian J</creator><creator>Alenina, Natalia</creator><creator>Bader, Michael</creator><creator>Santos, Robson A.S</creator><creator>Faraci, Frank M</creator><creator>Heistad, Donald D</creator><creator>Hasan, David M</creator><general>American Heart Association, Inc</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201408</creationdate><title>Angiotensin 1–7 Reduces Mortality and Rupture of Intracranial Aneurysms in Mice</title><author>Peña Silva, Ricardo A ; Kung, David K ; Mitchell, Ian J ; Alenina, Natalia ; Bader, Michael ; Santos, Robson A.S ; Faraci, Frank M ; Heistad, Donald D ; Hasan, David M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6435-f6a753ddb86d21a8f6e5795fc57047285dd8b74e0c0c0026eb8fe39f40f3bd353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aneurysm, Ruptured - drug therapy</topic><topic>Aneurysm, Ruptured - mortality</topic><topic>Aneurysm, Ruptured - prevention & control</topic><topic>Angiotensin I - pharmacology</topic><topic>Angiotensin I - therapeutic use</topic><topic>Animals</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Blood Pressure - drug effects</topic><topic>Cardiology. Vascular system</topic><topic>Humans</topic><topic>Intracranial Aneurysm - drug therapy</topic><topic>Intracranial Aneurysm - mortality</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Knockout</topic><topic>Neurology</topic><topic>Oxidative Stress - drug effects</topic><topic>Peptide Fragments - pharmacology</topic><topic>Peptide Fragments - therapeutic use</topic><topic>Proto-Oncogene Proteins - genetics</topic><topic>Proto-Oncogene Proteins - metabolism</topic><topic>Receptors, G-Protein-Coupled - genetics</topic><topic>Receptors, G-Protein-Coupled - metabolism</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Peña Silva, Ricardo A</creatorcontrib><creatorcontrib>Kung, David K</creatorcontrib><creatorcontrib>Mitchell, Ian J</creatorcontrib><creatorcontrib>Alenina, Natalia</creatorcontrib><creatorcontrib>Bader, Michael</creatorcontrib><creatorcontrib>Santos, Robson A.S</creatorcontrib><creatorcontrib>Faraci, Frank M</creatorcontrib><creatorcontrib>Heistad, Donald D</creatorcontrib><creatorcontrib>Hasan, David M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Hypertension (Dallas, Tex. 1979)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Peña Silva, Ricardo A</au><au>Kung, David K</au><au>Mitchell, Ian J</au><au>Alenina, Natalia</au><au>Bader, Michael</au><au>Santos, Robson A.S</au><au>Faraci, Frank M</au><au>Heistad, Donald D</au><au>Hasan, David M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Angiotensin 1–7 Reduces Mortality and Rupture of Intracranial Aneurysms in Mice</atitle><jtitle>Hypertension (Dallas, Tex. 1979)</jtitle><addtitle>Hypertension</addtitle><date>2014-08</date><risdate>2014</risdate><volume>64</volume><issue>2</issue><spage>362</spage><epage>368</epage><pages>362-368</pages><issn>0194-911X</issn><eissn>1524-4563</eissn><coden>HPRTDN</coden><abstract>Angiotensin II (Ang II) stimulates vascular inflammation, oxidative stress, and formation and rupture of intracranial aneurysms in mice. Because Ang 1–7 acts on Mas receptors and generally counteracts deleterious effects of Ang II, we tested the hypothesis that Ang 1–7 attenuates formation and rupture of intracranial aneurysms. Intracranial aneurysms were induced in wild-type and Mas receptor–deficient mice using a combination of Ang II–induced hypertension and intracranial injection of elastase in the basal cistern. Mice received elastase+Ang II alone or a combination of elastase+Ang II+Ang 1–7. Aneurysm formation, prevalence of subarachnoid hemorrhage, mortality, and expression of molecules involved in vascular injury were assessed. Systolic blood pressure was similar in mice receiving elastase+Ang II (mean±SE, 148±5 mm Hg) or elastase+Ang II+Ang 1–7 (144±5 mm Hg). Aneurysm formation was also similar in mice receiving elastase+Ang II (89%) or elastase+Ang II+Ang 1–7 (84%). However, mice that received elastase+Ang II+Ang 1–7 had reduced mortality (from 64% to 36%; P<0.05) and prevalence of subarachnoid hemorrhage (from 75% to 48%; P<0.05). In cerebral arteries, expression of the inflammatory markers, Nox2 and catalase increased similarly in elastase+Ang II or elastase+Ang II+Ang 1–7 groups. Ang 1–7 increased the expression of cyclooxygenase-2 and decreased the expression of matrix metalloproteinase-9 induced by elastase+Ang II (P<0.05). In Mas receptor–deficient mice, systolic blood pressure, mortality, and prevalence of subarachnoid hemorrhage were similar (P>0.05) in groups treated with elastase+Ang II or elastase+Ang II+Ang 1–7. The expression of Mas receptor was detected by immunohistochemistry in samples of human intracranial arteries and aneurysms. In conclusion, without attenuating Ang II–induced hypertension, Ang 1–7 decreased mortality and rupture of intracranial aneurysms in mice through a Mas receptor–dependent pathway.</abstract><cop>Hagerstown, MD</cop><pub>American Heart Association, Inc</pub><pmid>24799613</pmid><doi>10.1161/HYPERTENSIONAHA.114.03415</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0194-911X |
| ispartof | Hypertension (Dallas, Tex. 1979), 2014-08, Vol.64 (2), p.362-368 |
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| source | MEDLINE; American Heart Association Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete |
| subjects | Aneurysm, Ruptured - drug therapy Aneurysm, Ruptured - mortality Aneurysm, Ruptured - prevention & control Angiotensin I - pharmacology Angiotensin I - therapeutic use Animals Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Blood Pressure - drug effects Cardiology. Vascular system Humans Intracranial Aneurysm - drug therapy Intracranial Aneurysm - mortality Medical sciences Mice Mice, Knockout Neurology Oxidative Stress - drug effects Peptide Fragments - pharmacology Peptide Fragments - therapeutic use Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Vascular diseases and vascular malformations of the nervous system |
| title | Angiotensin 1–7 Reduces Mortality and Rupture of Intracranial Aneurysms in Mice |
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