The role of PML in hematopoietic and leukemic stem cell maintenance

The tumor suppressor promyelocytic leukemia (PML) was first identified as a component of PML–RARα fusion protein, one of the initiating cytogenetic abnormalities in acute promyelocytic leukemia. PML is now known to have diverse functions regulating the DNA-damage response, apoptosis, senescence, and...

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Veröffentlicht in:	International journal of hematology 2014-07, Vol.100 (1), p.18-26
Hauptverfasser:	Nakahara, Fumio, Weiss, Cary N., Ito, Keisuke
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - therapeutic use Arsenicals - therapeutic use Fatty Acids - metabolism Hematology Hematopoietic Stem Cells - metabolism Hematopoietic Stem Cells - pathology Humans Leukemia, Promyelocytic, Acute - drug therapy Leukemia, Promyelocytic, Acute - genetics Leukemia, Promyelocytic, Acute - metabolism Leukemia, Promyelocytic, Acute - pathology Medicine Medicine & Public Health Nuclear Proteins - genetics Nuclear Proteins - metabolism Oncogene Proteins, Fusion - genetics Oncogene Proteins, Fusion - metabolism Oncology Oxides - therapeutic use Progress in Hematology Promyelocytic Leukemia Protein Signal Transduction - drug effects Transcription Factors - genetics Transcription Factors - metabolism Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism
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