microRNA Signature and Expression of Dicer and Drosha Can Predict Prognosis and Delineate Risk Groups in Neuroblastoma

Neuroblastoma is a common childhood tumor and accounts for 15% of pediatric cancer deaths. To investigate the microRNA (miRNA) profile and role of Dicer and Drosha in neuroblastoma, we assessed the expression of 162 human miRNAs, Dicer and Drosha in 66 neuroblastoma tumors by using real-time PCR met...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2010-10, Vol.70 (20), p.7841-7850
Hauptverfasser:	LIN, Ruey-Jen, LIN, You-Chin, CHEN, Jeremy, KUO, Huan-Hsien, CHEN, Yuan-Yan, DICCIANN, Mitchell B, LONDON, Wendy B, CHANG, Chih-Hao, YU, Alice L
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Biological and medical sciences Cell Line, Tumor Colony-Forming Units Assay DNA Primers Gene Expression Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic Gene Silencing Humans Medical sciences MicroRNAs - genetics Neuroblastoma - enzymology Neuroblastoma - epidemiology Neuroblastoma - genetics Neurology Pharmacology. Drug treatments Plasmids Polymerase Chain Reaction - methods Predictive Value of Tests Prognosis Ribonuclease III - deficiency Ribonuclease III - genetics Risk Assessment RNA, Messenger - genetics RNA, Neoplasm - genetics Transfection Tumors Tumors of the nervous system. Phacomatoses
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