Role of miR-146a in human chondrocyte apoptosis in response to mechanical pressure injury in vitro

MicroRNA (miR)-146a is known to be overexpressed in osteoarthritis (OA). However, the role of miR-146a in OA has not yet been fully elucidated. In the present study, we applied mechanical pressure of 10 MPa to human chondrocytes for 60 min in order to investigate the expression of miR-146a and apopt...

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Veröffentlicht in:	International journal of molecular medicine 2014-08, Vol.34 (2), p.451-463
Hauptverfasser:	JIN, LEI, ZHAO, JIAN, JING, WENSEN, YAN, SHIJU, WANG, XIN, XIAO, CHUN, MA, BAOAN
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Apoptosis - genetics Arthritis Cartilage, Articular - metabolism Cell Proliferation - genetics chondrocyte Chondrocytes - metabolism Chondrocytes - pathology Development and progression Gene expression Gene Expression Regulation Genes Genetic aspects Health aspects Homeostasis Humans In Vitro Techniques Inflammation Injuries Kinases mechanical injury MicroRNA MicroRNAs - biosynthesis MicroRNAs - genetics miR-146a Osteoarthritis Osteoarthritis - genetics Osteoarthritis - metabolism Osteoarthritis - pathology Pathogenesis Physiology Pressure Ulcer - metabolism Pressure Ulcer - pathology Pressure ulcers Proteins RNA, Messenger - biosynthesis Stress, Mechanical Studies Tumor necrosis factor-TNF Vascular endothelial growth factor Vascular Endothelial Growth Factor A - biosynthesis Wounds and Injuries - metabolism Wounds and Injuries - pathology
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