Pathogenetic importance and therapeutic implications of NF-κB in lymphoid malignancies

Derangement of the nuclear factor κB (NF‐κB) pathway initiates and/or sustains many types of human cancer. B‐cell malignancies are particularly affected by oncogenic mutations, translocations, and copy number alterations affecting key components the NF‐κB pathway, most likely owing to the pervasive...

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