Dengue virus- and hepatitis C virus-induced replication and assembly compartments: the enemy inside--caught in the web

Dengue virus (DENV) and hepatitis C virus (HCV), members of the family Flaviviridae, are global human health concerns. As positive-strand RNA viruses, they each replicate in the cytoplasm of infected cells and induce distinct membranous replication compartments where most, if not all, steps of the v...

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Veröffentlicht in:Journal of virology 2014-06, Vol.88 (11), p.5907-5911
Hauptverfasser: Chatel-Chaix, Laurent, Bartenschlager, Ralf
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container_title Journal of virology
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creator Chatel-Chaix, Laurent
Bartenschlager, Ralf
description Dengue virus (DENV) and hepatitis C virus (HCV), members of the family Flaviviridae, are global human health concerns. As positive-strand RNA viruses, they each replicate in the cytoplasm of infected cells and induce distinct membranous replication compartments where most, if not all, steps of the viral life cycle occur. This Gem briefly reviews the most recent insights into the architecture and functional properties of membranous replication and assembly sites induced by DENV and HCV.
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subjects Cytoplasmic Vesicles - ultrastructure
Cytoplasmic Vesicles - virology
Dengue virus
Dengue Virus - physiology
Flaviviridae
Gem
Hepacivirus - physiology
Hepatitis C virus
Humans
Intracellular Membranes - metabolism
Intracellular Membranes - virology
Virus Assembly - physiology
Virus Replication - physiology
title Dengue virus- and hepatitis C virus-induced replication and assembly compartments: the enemy inside--caught in the web
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