Structural analysis of determinants of histo-blood group antigen binding specificity in genogroup I noroviruses

Human noroviruses (NoVs) cause acute epidemic gastroenteritis. Susceptibility to the majority of NoV infections is determined by genetically controlled secretor-dependent expression of histo-blood group antigens (HBGAs), which are also critical for NoV attachment to host cells. Human NoVs are classi...

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Veröffentlicht in:	Journal of virology 2014-06, Vol.88 (11), p.6168-6180
Hauptverfasser:	Shanker, Sreejesh, Czako, Rita, Sankaran, Banumathi, Atmar, Robert L, Estes, Mary K, Prasad, B V Venkataram
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Antigens, Viral - metabolism Base Sequence Blotting, Western Crystallography Dimerization Enzyme-Linked Immunosorbent Assay Epitopes - genetics Epitopes - metabolism Genotype Humans Models, Molecular Molecular Sequence Data Norovirus Norovirus - metabolism Protein Structure, Tertiary Sequence Alignment Sequence Analysis, DNA Structure and Assembly Viral Structural Proteins - chemistry Viral Structural Proteins - metabolism Virus Attachment X-Ray Diffraction
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