Human metapneumovirus virus-like particles induce protective B and T cell responses in a mouse model

Human metapneumovirus (HMPV) is a leading cause of respiratory disease in infants, children, and the elderly worldwide, yet no licensed vaccines exist. Live-attenuated vaccines present safety challenges, and protein subunit vaccines induce primarily antibody responses. Virus-like particles (VLPs) ar...

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Veröffentlicht in:	Journal of virology 2014-06, Vol.88 (11), p.6368-6379
Hauptverfasser:	Cox, Reagan G, Erickson, John J, Hastings, Andrew K, Becker, Jennifer C, Johnson, Monika, Craven, Ryan E, Tollefson, Sharon J, Boyd, Kelli L, Williams, John V
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Antibodies, Neutralizing - immunology B-Lymphocytes - immunology Blotting, Western CD8-Positive T-Lymphocytes - immunology Enzyme-Linked Immunosorbent Assay Enzyme-Linked Immunospot Assay Flow Cytometry Galactosylceramides HEK293 Cells Human metapneumovirus Humans Immunity, Cellular - immunology Immunohistochemistry Lung - immunology Lung - pathology Metapneumovirus - immunology Mice Mice, Inbred C57BL Microscopy, Electron, Transmission Poloxalene Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction Vaccines and Antiviral Agents Vaccines, Virus-Like Particle - immunology Vaccines, Virus-Like Particle - ultrastructure
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